ChemicalBook > CAS DataBase List > CCF-642

CCF-642

Product Name
CCF-642
CAS No.
346640-08-2
Chemical Name
CCF-642
Synonyms
CCF-642;AC1LYELL;CCF 642, ≥98%;CCF 642;CCF-642;CCF642 >=98% (HPLC);CCF 642;CCF-642;AC1LYELL;3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-;3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one;calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642
CBNumber
CB13133223
Molecular Formula
C15H10N2O4S3
Formula Weight
378.45
MOL File
346640-08-2.mol
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CCF-642 Property

Boiling point:
567.3±60.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:14.4(Max Conc. mg/mL);38.05(Max Conc. mM)
form 
powder
pka
-0.70±0.20(Predicted)
color 
yellow to orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1827
Product name
CCF642
Purity
≥98% (HPLC)
Packaging
5mg
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1827
Product name
CCF642
Purity
≥98% (HPLC)
Packaging
25mg
Price
$464
Updated
2024/03/01
Cayman Chemical
Product number
27054
Product name
CCF-642
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
27054
Product name
CCF-642
Packaging
25mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
27054
Product name
CCF-642
Packaging
1mg
Price
$32
Updated
2024/03/01
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CCF-642 Chemical Properties,Usage,Production

Uses

CCF642 has been used as a protein disulfide isomerase (PDI) inhibitor to study its ability to reduce the expression of endoplasmic reticulum (ER) stress markers and neuroinflammation in the hippocampus of experimental autoimmune encephalomyelitis (EAE) mice.

Biochem/physiol Actions

CCF642 is a cell-permeable protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action that most likely involves PDI active-site CGHCK motifs instead of cysteine known to be targeted by PACMA 31. CCF642 displays anti-multiple myeloma (MM) activity both in cultures in vitro (IC50 <1 μM against murine 5TGM1 and nine human MM lines) and in mice in vivo (10 mg/kg, 3X i.p. per wk) without apparent adverse effects to the animals or being cytotoxic to normal bone marrow (NLBM) cells even at concentrations as high as 6.75 μM. Consistent with PDI′s role in ER protein folding process, CCF642 treatment causes acute ER stress accompanied by apoptosis-inducing calcium release in MM cells.

CCF-642 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCF-642 Suppliers

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346640-08-2, CCF-642Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CC-885 CCT245737 4-Methoxy-3-nitrobenzoic acid

  • CCF-642
  • 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
  • CCF 642;CCF-642
  • AC1LYELL
  • CCF 642;CCF-642;AC1LYELL
  • 4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-
  • CCF642 >=98% (HPLC)
  • CCF 642, ≥98%
  • 3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one
  • calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642
  • 346640-08-2