CC-885

Product Name: CC-885
CAS No.: 1010100-07-8
Chemical Name: CC-885
Synonyms: CC-885;CC-885 ，S8300;CC-885, 10 mM in DMSO;Ligands for E3 Ligase,CC-885,CC 885,E3 ligase-recruiting Moiety,CC885,Inhibitor,inhibit;1-(3-Chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea;N-(3-Chloro-4-methylphenyl)-N′-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]urea;Urea, N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-
CBNumber: CB13159377
Molecular Formula: C22H21ClN4O4
Formula Weight: 440.88
MOL File: 1010100-07-8.mol

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CC-885 Property

storage temp.: Storage temp. -20°C
solubility: DMSO:40.0(Max Conc. mg/mL);90.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.45(Max Conc. mM)
DMF:12.5(Max Conc. mg/mL);28.35(Max Conc. mM)
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19966
Product name: CC-885
Purity: ≥98%
Packaging: 500μg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 19966
Product name: CC-885
Purity: ≥98%
Packaging: 1mg
Price: $171
Updated: 2024/03/01

Cayman Chemical

Product number: 19966
Product name: CC-885
Purity: ≥98%
Packaging: 5mg
Price: $578
Updated: 2024/03/01

Cayman Chemical

Product number: 19966
Product name: CC-885
Purity: ≥98%
Packaging: 10mg
Price: $886
Updated: 2024/03/01

AK Scientific

Product number: 1485DC
Product name: 1-(3-Chloro-4-methylphenyl)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea
Packaging: 1mg
Price: $293
Updated: 2021/12/16

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CC-885 Chemical Properties,Usage,Production

Description

CC-885 is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1. was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1). GSPT1 (also named eRF3a) is a translation termination factor that binds eukaryotic translation termination factor 1 (eFR1) to mediate stop codon recognition and nascent protein release from the ribosome.

Uses

CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation.

target

CC-885 is a cereblon (CRBN) modulator.

IC 50

Cereblon

References

[1] Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. DOI:10.1038/nature18611
[2] Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders[J]. bioRxiv, 2024: 2024.01. 28.577572.

CC-885 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-885 Suppliers

China 74 United States 6 USA 1 Global 81

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 977
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 88915
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29661
Advantage: 68

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1946
Advantage: 55

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 24972
Advantage: 58

1010100-07-8, CC-885Related Search:

CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- CCT245737 CCF-642

CC-885

Urea, N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-

1-(3-Chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea

Ligands for E3 Ligase,CC-885,CC 885,E3 ligase-recruiting Moiety,CC885,Inhibitor,inhibit

CC-885, 10 mM in DMSO

CC-885 ，S8300

N-(3-Chloro-4-methylphenyl)-N′-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]urea

1010100-07-8