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CCT196969

Product Name
CCT196969
CAS No.
1163719-56-9
Chemical Name
CCT196969
Synonyms
CS-2447;CCT196969;CCT196969 ，S7743;CCT196969 (CCT-196969;CCT196969, 10 mM in DMSO;CCT196969; CCT-196969; CCT 196969;CCT 196969,Raf,CCT196969,CCT-196969,Inhibitor,inhibit,Raf kinases;1-(3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyra;Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-
CBNumber
CB93134226
Molecular Formula
C27H24FN7O3
Formula Weight
513.52
MOL File
1163719-56-9.mol
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CCT196969 Property

storage temp. 
Store at -20°C
solubility 
DMSO: Soluble
form 
A solid
color 
White to off-white
InChIKey
KYYKGSDLXXKQCR-UHFFFAOYSA-N
SMILES
N(C1=CC=C(OC2=C3N=CC(=O)NC3=NC=C2)C=C1F)C(NC1N(C2=CC=CC=C2)N=C(C(C)(C)C)C=1)=O
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
25537
Product name
CCT196969
Purity
≥95%
Packaging
25mg
Price
$343
Updated
2024/03/01
TRC
Product number
C227940
Product name
CCT196969
Packaging
100mg
Price
$685
Updated
2021/12/16
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CCT196969 Chemical Properties,Usage,Production

Uses

CCT196969 is a paradox-breaking RAF inhibitor that also targets SRC and is thus effective in drug-resistant BRAF mutant melanoma.

in vivo

CCT196969 is extremely well tolerated and does not produce any significant adverse effects in vivo. It inhibits the growth of NRAS mutant DO4 tumor xenografts in nude mice. CCT196969 inhibits ERK and SRC and induce tumor regression in a PDX from the resistant tumor without causing body weight loss in the mice[1].

IC 50

BRafV600E: 0.04 μM (IC50); Braf: 0.1 μM (IC50); CRAF: 0.01 μM (IC50); LCK: 0.02 μM (IC50); SRC: 0.03 μM (IC50)

CCT196969 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT196969 Suppliers

China 59 United States 10 Global 69
Nantong Innova Pharma-Tech Co., Ltd.
Tel
0513-80339088 13862859328
Fax
0513-80339088
Email
zyz.80@163.com
Country
China
ProdList
160
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
1250
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29759
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58

1163719-56-9, CCT196969Related Search:

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide CCT245737 3H-IMidazo[4,5-b]pyridine, 6-chloro-7-[4-[(4-chlorophenyl)Methyl]-1-piperazinyl]-2-(1,3-diMethyl-1H-pyrazol-4-yl)-

  • CCT196969
  • 1-(3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyra
  • CCT196969; CCT-196969; CCT 196969
  • CS-2447
  • Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-
  • CCT 196969,Raf,CCT196969,CCT-196969,Inhibitor,inhibit,Raf kinases
  • CCT196969, 10 mM in DMSO
  • CCT196969 ，S7743
  • CCT196969 (CCT-196969
  • 1163719-56-9
  • C27H24FN7O3