1,7-Naphthyridin-8(7H)-one, 3-bromo-

Product Name: 1,7-Naphthyridin-8(7H)-one, 3-bromo-
CAS No.: 1375301-90-8
Chemical Name: 1,7-Naphthyridin-8(7H)-one, 3-bromo-
Synonyms: 7-naphthyridin-8(7H)-one;3-bromo-7H-[1,7]naphthyridin-8-one;3-Bromo-1,7-naphthyridin-8(7H)-one;1,7-Naphthyridin-8(7H)-one, 3-bromo-;3-bromo-7,8-dihydro-1,7-naphthyridin-8-one;3-bromo-1,7-naphthyridin-8-ol, 3-Bromo-1,7-naphthyridin-8(7H)-one
CBNumber: CB93144911
Molecular Formula: C8H5BrN2O
Formula Weight: 225.04
MOL File: 1375301-90-8.mol

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1,7-Naphthyridin-8(7H)-one, 3-bromo- Property

Boiling point:: 468.9±45.0 °C(Predicted)
Density: 1.711±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 10.80±0.20(Predicted)
Appearance: Off-white to brown Solid
InChI: InChI=1S/C8H5BrN2O/c9-6-3-5-1-2-10-8(12)7(5)11-4-6/h1-4H,(H,10,12)
InChIKey: GUOAFNIATRDFCL-UHFFFAOYSA-N
SMILES: N1C2=C(C=CNC2=O)C=C(Br)C=1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B606855
Product name: 3-bromo-1,7-naphthyridin-8-ol
Packaging: 25mg
Price: $285
Updated: 2021/12/16

Apolloscientific

Product number: OR500038
Product name: 3-Bromo-1,7-naphthyridin-8(7H)-one
Purity: 97%
Packaging: 250mg
Price: $77
Updated: 2021/12/16

Apolloscientific

Product number: OR500038
Product name: 3-Bromo-1,7-naphthyridin-8(7H)-one
Purity: 97%
Packaging: 1g
Price: $198
Updated: 2021/12/16

Crysdot

Product number: CD11269562
Product name: 3-Bromo-1,7-naphthyridin-8(7H)-one
Purity: 97%
Packaging: 5g
Price: $550
Updated: 2021/12/16

Crysdot

Product number: CD11269562
Product name: 3-Bromo-1,7-naphthyridin-8(7H)-one
Purity: 97%
Packaging: 10g
Price: $916
Updated: 2021/12/16

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1,7-Naphthyridin-8(7H)-one, 3-bromo- Chemical Properties,Usage,Production

Synthesis

1429870-16-5

1375301-90-8

5-Bromo-3-methylpyridine-2-carboxylic acid 1-dimethylaminomethyl-(E)-imide (2.5 g, 9.25 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 20 mL). A solution of potassium tert-butanolate (KOtBu, 1.565 g, 13.05 mmol) in THF (30 mL) was added dropwise under stirring. The reaction mixture was heated to reflux, maintained for 3 h and then cooled to room temperature. The pH of the reaction mixture was adjusted to 7 using concentrated hydrochloric acid (HCl). subsequently, the reaction mixture was concentrated to give a brown solid. This solid was washed with water (10 mL) and collected by filtration to afford the target product 3-bromo-1,7-naphthyridin-8-(7H)-one (2 g, 8 mmol). The product was analyzed by high performance liquid chromatography (HPLC) with a retention time (RtH9) of 0.56 min; electrospray ionization mass spectrometry (ESIMS) showed [M + H]+ peaks of 224.8 and 226.8 (containing 1 bromine atom); and the chemical shifts of nuclear magnetic resonance hydrogen spectra (1H-NMR, 400 MHz, DMSO-d6) were δ11.9 (s, 1H), 8.85 (s, 1H), 8.50 (s, 1H), 7.43 (d, 1H), 6.67 (d, 1H).

References

[1] Patent: WO2013/54291, 2013, A1. Location in patent: Page/Page column 77

1,7-Naphthyridin-8(7H)-one, 3-bromo- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,7-Naphthyridin-8(7H)-one, 3-bromo- Suppliers

China 57 India 1 United States 3 Global 61

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1375301-90-8, 1,7-Naphthyridin-8(7H)-one, 3-bromo-Related Search:

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