GSK 2033
- Product Name
- GSK 2033
- CAS No.
- 1221277-90-2
- Chemical Name
- GSK 2033
- Synonyms
- GSK 2033;LXR antagonist 2033;GSK2033 >=98% (HPLC);Liver X receptor,Inhibitor,GSK 2033,inhibit,LXR,GSK2033,GSK-2033;2,4,6-Trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide;2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-benzenesulfonamide;Benzenesulfonamide, 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-
- CBNumber
- CB93146298
- Molecular Formula
- C29H28F3NO5S2
- Formula Weight
- 591.66
- MOL File
- 1221277-90-2.mol
GSK 2033 Property
- storage temp.
- 2-8°C
- solubility
- DMF:5.0(Max Conc. mg/mL);8.45(Max Conc. mM)
DMSO:17.46(Max Conc. mg/mL);29.51(Max Conc. mM) - form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1617
- Product name
- GSK2033
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $159
- Updated
- 2023/06/20
- Product number
- SML1617
- Product name
- GSK2033
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $639
- Updated
- 2023/06/20
- Product number
- 25443
- Product name
- GSK2033
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 25443
- Product name
- GSK2033
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 25443
- Product name
- GSK2033
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
GSK 2033 Chemical Properties,Usage,Production
Uses
GSK 2033 is a potent LXR antagonist.
Biochem/physiol Actions
GSK2033 is an antagonist of the nuclear receptor liver-X-receptor (LXR) with pIC50 values of 7.0 for LXRα and 7.4 for LXRβ. Treatment of murine CD41 T cells with GSK2033 enhanced cellular proliferation and Th1/Th2/Th17 differentiation. In another study, the conjugated linoleic acid (CLA)-induced expression of efflux protein ATP-binding-cassette transporter A1 (ABCA1) was completely abolished by preincubation with GSK2033, showing that CLA mediated regulation of ABCA-1 expression is LXR dependent.
storage
Store at +4°C
GSK 2033 Preparation Products And Raw materials
Raw materials
Preparation Products
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