GSK2636771

Product Name: GSK2636771
CAS No.: 1372540-25-4
Chemical Name: GSK2636771
Synonyms: CS-357;GSK2636771;GSK 2636771B;GSK2636771cas;GSK2636771 USP/EP/BP;GSK2636771/GSK-2636771;GSK 2636771 dihydrochloride;PI3Kβ-selective inhibitor GS2636771;2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic;2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid
CBNumber: CB52624179
Molecular Formula: C22H22F3N3O3
Formula Weight: 433.42
MOL File: 1372540-25-4.mol

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GSK2636771 Property

Melting point:: >225°C (dec.)
Boiling point:: 641.3±55.0 °C(Predicted)
Density: 1.38
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: -2.70±0.30(Predicted)
form: Solid
color: Pale Yellow
InChI: InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
InChIKey: XTKLTGBKIDQGQL-UHFFFAOYSA-N
SMILES: C1(C)N(CC2=CC=CC(C(F)(F)F)=C2C)C2=CC(N3CCOCC3)=CC(C(O)=O)=C2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17380
Product name: GSK2636771
Purity: ≥98%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17380
Product name: GSK2636771
Purity: ≥98%
Packaging: 1mg
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 17380
Product name: GSK2636771
Purity: ≥98%
Packaging: 5mg
Price: $278
Updated: 2024/03/01

Cayman Chemical

Product number: 17380
Product name: GSK2636771
Purity: ≥98%
Packaging: 10mg
Price: $384
Updated: 2024/03/01

Usbiological

Product number: 451491
Product name: GSK2636771
Packaging: 2.5mg
Price: $403
Updated: 2021/12/16

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GSK2636771 Chemical Properties,Usage,Production

Description

GSK2636771 is a potent, orally bioavailable, adenosine triphosphate-competitive, selective inhibitor of PI3Kβ with an apparent Ki value of 0.89 nmol/L (IC50 = 5.2 nmol/L), >900-fold selectivity over p110α and p110γ, and >10-fold selectivity over p110δ isoforms, while sparing other PI3K superfamily kinases[1-2].

Uses

GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines.

in vitro

GSK-2636771 shows selectively inhibitory activity in PTEN null cell lines (human prostate adenocarcinoma PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. GSK2636771 significantly decreases cell viability in p110β-reliant PTEN-deficient PC3 prostate and BT549 and HCC70 breast cancer cell lines. It leads to a marked decrease of AKT phosphorylation only in the control prostate and breast cancer cell lines.

References

[1] Mateo, Joaquin , et al. "A first-time-in-human study of GSK2636771, a phosphoinositide 3 kinase beta-selective inhibitor, in patients with advanced solid tumors." Clinical Cancer Research (2017):clincanres.0725.2017.
[2] Sarker, Debashis , et al. "A Phase I, Open-Label, Dose-Finding Study of GSK2636771, a PI3Kβ Inhibitor, Administered with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer." Clinical Cancer Research 27.19(2021):5248-5257.

GSK2636771 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2636771 Suppliers

China 127 United States 18 Global 145

Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

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Jinan Trio PharmaTech Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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Email: meilunui@163.com
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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Haoyuan Chemexpress Co., Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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MedChemexpress LLC

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Guangzhou Isun Pharmaceutical Co., Ltd

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AdooQ BioScience, LLC

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Country: United States
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View Lastest Price from GSK2636771 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: GSK-2636771 1372540-25-4
Price: US $0.00-0.00/mg
Min. Order: 1mg
Purity: 98%
Supply Ability: 20G
Release date: 2024-04-17

Henan Aochuang Chemical Co.,Ltd.

Product: GSK2636771 1372540-25-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: GSK2636771 1372540-25-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1372540-25-4, GSK2636771Related Search:

GSK-3326595 Bortezomib AZD6482 Alpelisib (BYL719) Pictilisib IPI 145 GSK-2256098 GSK369796 GSK2982772 MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel- GSK-2881078 GSK-2018682 GSK 2239633A GSK2838232 GSK2126458 GSK 2330672 GSK2795039 GSK2879552

GSK2636771

2-Methyl-1-[[2-Methyl-3-(trifluoroMethyl)phenyl]Methyl]-6-(4-Morpholinyl)-1H-benziMidazole-4-carboxylic acid

GSK2636771/GSK-2636771

GSK 2636771 dihydrochloride

2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic

1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-

2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid GSK2636771

2-METHYL-1-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]METHYL]-6-MORPHOLIN-4-YLBENZIMIDAZOLE-4-CARBOXYLIC ACID

2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(morpholin-4-yl)-1H-1,3-benzodiazole-4-carboxylic acid

CS-357

PI3Kβ-selective inhibitor GS2636771

GSK 2636771B

GSK2636771 USP/EP/BP

GSK2636771cas

2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid

1372540-25-4

Inhibitors

PI3K/Akt/mTOR

Akt

mTOR

PI3K

api

1372540-25-4