GSK 2330672
- Product Name
- GSK 2330672
- CAS No.
- 1345982-69-5
- Chemical Name
- GSK 2330672
- Synonyms
- linerixibat;CS-2639;GSK 2330672;Iinerixibat;linerixibat (GSK2330672);GSK 2330672; GSK-2330672;Iinerixibat (GSK2330672);3-((((3R,5R)-3-Butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl)methyl)amino)pentanedioic acid;Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)-;3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ6,4-benzothiazepin-8-yl]methylamino]pentanedioic acid
- CBNumber
- CB12716247
- Molecular Formula
- C28H38N2O7S
- Formula Weight
- 546.68
- MOL File
- 1345982-69-5.mol
GSK 2330672 Property
- Boiling point:
- 730.8±60.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.2 mg/ml
- form
- A crystalline solid
- pka
- 3.27±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H401Toxic to aquatic life
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23843
- Product name
- GSK2330672
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 23843
- Product name
- GSK2330672
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $515
- Updated
- 2024/03/01
- Product number
- 23843
- Product name
- GSK2330672
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $918
- Updated
- 2024/03/01
- Product number
- 4578DL
- Product name
- Linerixibat
- Packaging
- 5mg
- Price
- $671
- Updated
- 2021/12/16
- Product number
- CD31003808
- Product name
- GSK2330672
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $208
- Updated
- 2021/12/16
GSK 2330672 Chemical Properties,Usage,Production
Description
GSK2330672 is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively). In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 and plasma insulin in Zucker diabetic fatty (ZDF) rats.
GSK 2330672 Preparation Products And Raw materials
Raw materials
Preparation Products
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