ChemicalBook > CAS DataBase List > GSK 2330672

GSK 2330672

Product Name
GSK 2330672
CAS No.
1345982-69-5
Chemical Name
GSK 2330672
Synonyms
linerixibat;CS-2639;GSK 2330672;Iinerixibat;linerixibat (GSK2330672);GSK 2330672; GSK-2330672;Iinerixibat (GSK2330672);3-((((3R,5R)-3-Butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl)methyl)amino)pentanedioic acid;Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)-;3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ6,4-benzothiazepin-8-yl]methylamino]pentanedioic acid
CBNumber
CB12716247
Molecular Formula
C28H38N2O7S
Formula Weight
546.68
MOL File
1345982-69-5.mol
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GSK 2330672 Property

Boiling point:
730.8±60.0 °C(Predicted)
Density 
1.218±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.2 mg/ml
form 
A crystalline solid
pka
3.27±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23843
Product name
GSK2330672
Purity
≥98%
Packaging
1mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
23843
Product name
GSK2330672
Purity
≥98%
Packaging
5mg
Price
$515
Updated
2024/03/01
Cayman Chemical
Product number
23843
Product name
GSK2330672
Purity
≥98%
Packaging
10mg
Price
$918
Updated
2024/03/01
AK Scientific
Product number
4578DL
Product name
Linerixibat
Packaging
5mg
Price
$671
Updated
2021/12/16
Crysdot
Product number
CD31003808
Product name
GSK2330672
Purity
98+%
Packaging
5mg
Price
$208
Updated
2021/12/16
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GSK 2330672 Chemical Properties,Usage,Production

Description

GSK2330672 is an inhibitor of the apical sodium-dependent bile acid transporter (ASBT; IC50s = 42, 2.1, and 1.9 nM for human, mouse, and rat ASBT, respectively). In vivo, GSK2330672 (0.05 mg/kg) stimulates fecal bile acid secretion, reduces hemoglobin A1c (HbA1c) and plasma glucose levels, and increases total GLP-1 and plasma insulin in Zucker diabetic fatty (ZDF) rats.

GSK 2330672 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK 2330672 Suppliers

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1345982-69-5, GSK 2330672Related Search:

GSK2814338 GSK-2256098 GSK-25 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK 2801 GSK2636771 GSK2879552 GSK2795039 GSK2838232

  • GSK 2330672; GSK-2330672
  • GSK 2330672
  • 3-[[(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxo-5-phenyl-4,5-dihydro-2H-1λ<sup>6</sup>,4-benzothiazepin-8-yl]methylamino]pentanedioic acid
  • Pentanedioic acid, 3-((((3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl)methyl)amino)-
  • CS-2639
  • Iinerixibat
  • linerixibat
  • Iinerixibat (GSK2330672)
  • type-2,PBC,lipid-lowering,solubility,nonabsorbable,GSK-2330672,Inhibitor,Primary,diabetes,GSK 2330672,Cholangitis,inhibit,Linerixibat,aqueous,Biliary,ASBT
  • linerixibat (GSK2330672)
  • 3-((((3R,5R)-3-Butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl)methyl)amino)pentanedioic acid
  • 1345982-69-5