GSK-25

Product Name: GSK-25
CAS No.: 874119-56-9
Chemical Name: GSK-25
Synonyms: GSK-25;GSK25;GSK 25;GSK-25, 10 mM in DMSO;4-(4-Chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4;4-(4-chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-1-(6-fluoro-1H-indazol-5-yl)-6-methyl-4H-pyrimidine-5-carboxamide;4-(4-Chloro-2-fluorophenyl)-2-(2-chloro-4-pyridyl)-N-(6-fluoro-5-indazolyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide;4-(4-Chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide;5-PyriMidinecarboxaMide, 4-(4-chloro-2-fluorophenyl)-2-(2-chloro-4-pyridinyl)-N-(6-fluoro-1H-indazol-5-yl)-1,4-dihydro-6-Methyl-;Rho-associated kinase,ROK,ROCK,Rho-associated protein kinase,S6K,bioavailable,Ribosomal S6 Kinase (RSK),Rho-kinase,Inhibitor,p70S6K,selective,pressure,P450,inhibit,GSK-25,GSK 25,blood,orally
CBNumber: CB82621139
Molecular Formula: C24H16Cl2F2N6O
Formula Weight: 513.33
MOL File: 874119-56-9.mol

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GSK-25 Property

Boiling point:: 751.7±60.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (194.81 mM)
form: Solid
pka: 11.61±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0003310
Product name: GSK-25
Purity: 99.68%
Packaging: 5mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-0003310
Product name: GSK-25
Purity: 99.68%
Packaging: 10mg
Price: $178
Updated: 2021/12/16

ChemScene

Product number: CS-0003310
Product name: GSK-25
Purity: 99.68%
Packaging: 25mg
Price: $255
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001346
Product name: GSK-25
Purity: 95.00%
Packaging: 1MG
Price: $340.2
Updated: 2021/12/16

ChemScene

Product number: CS-0003310
Product name: GSK-25
Purity: 99.68%
Packaging: 50mg
Price: $390
Updated: 2021/12/16

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GSK-25 Chemical Properties,Usage,Production

Uses

GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 μM). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 μM for CYP2C9, CYP2D6, CYP3A4, respectively)[1].

in vivo

GSK-25 (Rat aorta IC₅₀=256 nM) is profiled in a spontaneously hypertensive rat (SHR) model of hypertension. At 30 mg/kg (p.o.), GSK-25 induces a 25 mmHg (t=3 hours) drop in blood pressure^[1].
? GSK-25 has promising oral bioavailability (49% in male Sprague-Dawley rats and 19% in monkey), good half-life (1.8 hours in rat and 2.2 hours in monkey)^[1].

IC 50

ROCK1: 7 nM (IC₅₀); RSK1: 398 nM (IC₅₀); p70S6K: 1000 nM (IC₅₀)

References

[1] Sehon CA, et al. Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases. J Med Chem. 2008 Nov 13;51(21):6631-4. DOI:10.1021/jm8005096

GSK-25 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-25 Suppliers

CHINA 37 United Kingdom 1 United States 5 Global 43

Shanghai Boyle Chemical Co., Ltd.

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Lynnchem

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Novachemistry

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874119-56-9, GSK-25Related Search:

GSK2814338 GSK-2256098 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK 2801 GSK2636771 GSK2879552 GSK2795039 GSK 2330672 GSK2838232

4-(4-Chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

GSK-25

5-PyriMidinecarboxaMide, 4-(4-chloro-2-fluorophenyl)-2-(2-chloro-4-pyridinyl)-N-(6-fluoro-1H-indazol-5-yl)-1,4-dihydro-6-Methyl-

4-(4-Chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4

GSK25;GSK 25

4-(4-chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-1-(6-fluoro-1H-indazol-5-yl)-6-methyl-4H-pyrimidine-5-carboxamide

Rho-associated kinase,ROK,ROCK,Rho-associated protein kinase,S6K,bioavailable,Ribosomal S6 Kinase (RSK),Rho-kinase,Inhibitor,p70S6K,selective,pressure,P450,inhibit,GSK-25,GSK 25,blood,orally

4-(4-Chloro-2-fluorophenyl)-2-(2-chloro-4-pyridyl)-N-(6-fluoro-5-indazolyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

GSK-25, 10 mM in DMSO

874119-56-9