GSK2795039
- Product Name
- GSK2795039
- CAS No.
- 1415925-18-6
- Chemical Name
- GSK2795039
- Synonyms
- GSK2795039;GSK-2795039 (GSK 2795039;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
- CBNumber
- CB13152080
- Molecular Formula
- C23H26N6O2S
- Formula Weight
- 450.56
- MOL File
- 1415925-18-6.mol
GSK2795039 Property
- Boiling point:
- 691.5±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM) - form
- A solid
- pka
- 6.99±0.30(Predicted)
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML2770
- Product name
- GSK2795039
- Purity
- ≥98% (HPLC)
- Packaging
- 1MG
- Price
- $94.2
- Updated
- 2024/03/01
- Product number
- SML2770
- Product name
- GSK2795039
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $381
- Updated
- 2024/03/01
- Product number
- 6848
- Product name
- GSK2795039
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $505
- Updated
- 2021/12/16
- Product number
- CS-5988
- Product name
- GSK2795039
- Purity
- 98.14%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CS-5988
- Product name
- GSK2795039
- Purity
- 98.14%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
GSK2795039 Chemical Properties,Usage,Production
Biological Activity
GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.
in vitro
GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.
Apoptosis Analysis p>
| Cell Line: | PC12 cells |
| 25 μM | |
| Incubation Time: | < td class="col2"> 24 hours|
| Result: | Reduced apoptosis among PC12 cells. | td>
target
| Target | Value |
| ROS () | |
| NADPH () | |
| NOX2 (HRP/Amplex Red) (Cell-based assay) | 6.57( pIC50) |
storage
Store at -20°C
GSK2795039 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK2795039 Suppliers
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