ChemicalBook > CAS DataBase List > GSK2795039

GSK2795039

Uses

Product Name: GSK2795039
CAS No.: 1415925-18-6
Chemical Name: GSK2795039
Synonyms: GSK2795039;GSK2795039 ，S8974;GSK-2795039 (GSK 2795039;GSK2795039, 10 mM in DMSO;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
CBNumber: CB13152080
Molecular Formula: C23H26N6O2S
Formula Weight: 450.56
MOL File: 1415925-18-6.mol

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GSK2795039 Property

Boiling point:: 691.5±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM)
form: A solid
pka: 6.99±0.30(Predicted)
color: White to yellow
InChIKey: FMWVTCZKCXPKFW-UHFFFAOYSA-N
SMILES: N1(C)C=CC(S(NC2C=CN=C3N(C(C)C)C=C(C4=CC5=C(C=C4)CCN5C)C3=2)(=O)=O)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2770
Product name: GSK2795039
Purity: ≥98% (HPLC)
Packaging: 1MG
Price: $96.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2770
Product name: GSK2795039
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $392
Updated: 2025/07/31

Tocris

Product number: 6848
Product name: GSK2795039
Purity: ≥98%(HPLC)
Packaging: 25
Price: $505
Updated: 2021/12/16

ChemScene

Product number: CS-5988
Product name: GSK2795039
Purity: 98.14%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-5988
Product name: GSK2795039
Purity: 98.14%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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GSK2795039 Chemical Properties,Usage,Production

Uses

GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2), which can inhibit the production of reactive oxygen species (ROS), deplete NADPH, and reduce apoptosis.

Biological Activity

GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.

in vitro

GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.

Apoptosis Analysis p>

< td class="col1"> Concentration: < td class="col2"> 24 hours td>

Cell Line:	PC12 cells
25 μM
Incubation Time:
Result:	Reduced apoptosis among PC12 cells.

target

Target	Value
ROS ()
NADPH ()
NOX2 (HRP/Amplex Red) (Cell-based assay)	6.57( pIC50)

storage

Store at -20°C

GSK2795039 Preparation Products And Raw materials

Raw materials

Preparation Products

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1415925-18-6, GSK2795039Related Search:

GSK2814338 GSK-2256098 GSK-25 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK 2801 GSK2636771 GSK2879552 GSK 2330672 GSK2838232 D18

GSK2795039

N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

GSK-2795039 (GSK 2795039

1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-

Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039

GSK2795039, 10 mM in DMSO

GSK2795039 ，S8974

1415925-18-6