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GSK2795039

Product Name
GSK2795039
CAS No.
1415925-18-6
Chemical Name
GSK2795039
Synonyms
GSK2795039;GSK-2795039 (GSK 2795039;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
CBNumber
CB13152080
Molecular Formula
C23H26N6O2S
Formula Weight
450.56
MOL File
1415925-18-6.mol
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GSK2795039 Property

Boiling point:
691.5±65.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM)
form 
A solid
pka
6.99±0.30(Predicted)
color 
White to yellow
InChIKey
FMWVTCZKCXPKFW-UHFFFAOYSA-N
SMILES
N1(C)C=CC(S(NC2C=CN=C3N(C(C)C)C=C(C4=CC5=C(C=C4)CCN5C)C3=2)(=O)=O)=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2770
Product name
GSK2795039
Purity
≥98% (HPLC)
Packaging
1MG
Price
$94.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2770
Product name
GSK2795039
Purity
≥98% (HPLC)
Packaging
5MG
Price
$381
Updated
2024/03/01
Tocris
Product number
6848
Product name
GSK2795039
Purity
≥98%(HPLC)
Packaging
25
Price
$505
Updated
2021/12/16
ChemScene
Product number
CS-5988
Product name
GSK2795039
Purity
98.14%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-5988
Product name
GSK2795039
Purity
98.14%
Packaging
50mg
Price
$1800
Updated
2021/12/16
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GSK2795039 Chemical Properties,Usage,Production

Biological Activity

GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.

in vitro

GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.

Apoptosis Analysis p>

< td class="col1"> Concentration: < td class="col2"> 24 hours td>
Cell Line: PC12 cells
25 μM
Incubation Time:
Result: Reduced apoptosis among PC12 cells.

target

TargetValue
ROS
()
NADPH
()
NOX2 (HRP/Amplex Red)
(Cell-based assay)
6.57( pIC50)

storage

Store at -20°C

GSK2795039 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2795039 Suppliers

Shanghai Chaolan Chemical Technology Center
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1415925-18-6, GSK2795039Related Search:


  • GSK2795039
  • N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
  • GSK-2795039 (GSK 2795039
  • 1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
  • Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039
  • 1415925-18-6