ChemicalBook > CAS DataBase List > GSK2636771

GSK2636771

Product Name
GSK2636771
CAS No.
1372540-25-4
Chemical Name
GSK2636771
Synonyms
CS-357;GSK2636771;GSK 2636771B;GSK2636771cas;GSK2636771 USP/EP/BP;GSK2636771/GSK-2636771;GSK 2636771 dihydrochloride;PI3Kβ-selective inhibitor GS2636771;2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic;2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid
CBNumber
CB52624179
Molecular Formula
C22H22F3N3O3
Formula Weight
433.42
MOL File
1372540-25-4.mol
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GSK2636771 Property

Melting point:
>225°C (dec.)
Boiling point:
641.3±55.0 °C(Predicted)
Density 
1.38
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-2.70±0.30(Predicted)
form 
Solid
color 
Pale Yellow
InChI
InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
InChIKey
XTKLTGBKIDQGQL-UHFFFAOYSA-N
SMILES
C1(C)N(CC2=CC=CC(C(F)(F)F)=C2C)C2=CC(N3CCOCC3)=CC(C(O)=O)=C2N=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17380
Product name
GSK2636771
Purity
≥98%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17380
Product name
GSK2636771
Purity
≥98%
Packaging
1mg
Price
$74
Updated
2024/03/01
Cayman Chemical
Product number
17380
Product name
GSK2636771
Purity
≥98%
Packaging
5mg
Price
$278
Updated
2024/03/01
Cayman Chemical
Product number
17380
Product name
GSK2636771
Purity
≥98%
Packaging
10mg
Price
$384
Updated
2024/03/01
Usbiological
Product number
451491
Product name
GSK2636771
Packaging
2.5mg
Price
$403
Updated
2021/12/16
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GSK2636771 Chemical Properties,Usage,Production

Description

GSK2636771 is a potent, orally bioavailable, adenosine triphosphate-competitive, selective inhibitor of PI3Kβ with an apparent Ki value of 0.89 nmol/L (IC50 = 5.2 nmol/L), >900-fold selectivity over p110α and p110γ, and >10-fold selectivity over p110δ isoforms, while sparing other PI3K superfamily kinases[1-2].

Uses

GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines.

in vitro

GSK-2636771 shows selectively inhibitory activity in PTEN null cell lines (human prostate adenocarcinoma PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. GSK2636771 significantly decreases cell viability in p110β-reliant PTEN-deficient PC3 prostate and BT549 and HCC70 breast cancer cell lines. It leads to a marked decrease of AKT phosphorylation only in the control prostate and breast cancer cell lines.

References

[1] Mateo, Joaquin , et al. "A first-time-in-human study of GSK2636771, a phosphoinositide 3 kinase beta-selective inhibitor, in patients with advanced solid tumors." Clinical Cancer Research (2017):clincanres.0725.2017.
[2] Sarker, Debashis , et al. "A Phase I, Open-Label, Dose-Finding Study of GSK2636771, a PI3Kβ Inhibitor, Administered with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer." Clinical Cancer Research 27.19(2021):5248-5257.

GSK2636771 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2636771 Suppliers

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View Lastest Price from GSK2636771 manufacturers

Hubei Chuchang Biotech Co., Ltd.
Product
GSK-2636771 1372540-25-4
Price
US $0.00-0.00/mg
Min. Order
1mg
Purity
98%
Supply Ability
20G
Release date
2024-04-17
Henan Aochuang Chemical Co.,Ltd.
Product
GSK2636771 1372540-25-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
GSK2636771 1372540-25-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1372540-25-4, GSK2636771Related Search:

GSK-3326595 Bortezomib AZD6482 Alpelisib (BYL719) Pictilisib IPI 145 GSK-2256098 GSK369796 GSK2982772 MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel- GSK-2881078 GSK-2018682 GSK 2239633A GSK2838232 GSK2126458 GSK 2330672 GSK2795039 GSK2879552

  • GSK2636771
  • 2-Methyl-1-[[2-Methyl-3-(trifluoroMethyl)phenyl]Methyl]-6-(4-Morpholinyl)-1H-benziMidazole-4-carboxylic acid
  • GSK2636771/GSK-2636771
  • GSK 2636771 dihydrochloride
  • 2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic
  • 1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-
  • 2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid GSK2636771
  • 2-METHYL-1-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]METHYL]-6-MORPHOLIN-4-YLBENZIMIDAZOLE-4-CARBOXYLIC ACID
  • 2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(morpholin-4-yl)-1H-1,3-benzodiazole-4-carboxylic acid
  • CS-357
  • PI3Kβ-selective inhibitor GS2636771
  • GSK 2636771B
  • GSK2636771 USP/EP/BP
  • GSK2636771cas
  • 2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid
  • 1372540-25-4
  • Inhibitors
  • PI3K/Akt/mTOR
  • Akt
  • mTOR
  • PI3K
  • api
  • 1372540-25-4