BAY-1436032
- Product Name
- BAY-1436032
- CAS No.
- 1803274-65-8
- Chemical Name
- BAY-1436032
- Synonyms
- CS-2728;BAY-1436032;BAY 1436032 ，S8530;BAY-1436032, 10 mM in DMSO;Inhibitor,BAY1436032,Isocitrate Dehydrogenase (IDH),BAY-1436032,inhibit,BAY 1436032;2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-propanoic acid;1H-Benzimidazole-5-propanoic acid, 2-[[4-(trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-;3-(2-((4-(Trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid
- CBNumber
- CB93147619
- Molecular Formula
- C26H30F3N3O3
- Formula Weight
- 489.53
- MOL File
- 1803274-65-8.mol
BAY-1436032 Property
- Boiling point:
- 591.2±60.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:111.5(Max Conc. mg/mL);227.76(Max Conc. mM)
Ethanol:98.0(Max Conc. mg/mL);200.19(Max Conc. mM) - form
- A solid
- pka
- 4.34±0.10(Predicted)
- color
- White to gray
- InChIKey
- RNMAUIMMNAHKQR-QFBILLFUSA-N
- SMILES
- C1(NC2=CC=C(OC(F)(F)F)C=C2)N([C@@H]2C[C@H](C)CC(C)(C)C2)C2=CC=C(CCC(O)=O)C=C2N=1
N-Bromosuccinimide Price
- Product number
- B119020
- Product name
- BAY-1436032
- Packaging
- 1mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-0017982
- Product name
- BAY-1436032
- Purity
- 99.09%
- Packaging
- 5mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CS-0017982
- Product name
- BAY-1436032
- Purity
- 99.09%
- Packaging
- 10mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- CS-0017982
- Product name
- BAY-1436032
- Purity
- 99.09%
- Packaging
- 25mg
- Price
- $590
- Updated
- 2021/12/16
- Product number
- CS-0017982
- Product name
- BAY-1436032
- Purity
- 99.09%
- Packaging
- 50mg
- Price
- $990
- Updated
- 2021/12/16
BAY-1436032 Chemical Properties,Usage,Production
Uses
BAY-1436032, is a novel pan-mutant isocitrate dehydrogenase 1 (IDH1) inhibitor.
in vivo
Long-term exposure to once daily oral BAY-1436032 reveals nearly complete suppression of (R)-2-hydroxyglutarate (R-2HG) production with 150 mg/kg BAY1436032. White blood cell counts constantly increase in vehicle-treated mice and, at a lower rate, in animals receiving 45 mg/kg BAY-1436032, while they remain constant in the 150 mg/kg cohort. Hemoglobin levels are slightly lower in the vehicle and 45 mg/kg groups as compare to the 150 mg/kg cohort at day 60, while platelet counts are significantly reduced in vehicle and 45 mg/kg BAY-1436032 treated mice compare to the 150 mg/kg cohort at day 60. All mice receiving 150 mg/kg BAY-1436032 survive with minimal hCD45+ cell load in their peripheral blood until the end of observation at day 150 after treatment start (P<0.001), while vehicle-treated animals die from leukemia with a median survival of 91 days. Mice treated with 45 mg/kg BAY-1436032 display intermediate levels of CD14/CD15 expression[1].
IC 50
IDH1
BAY-1436032 Preparation Products And Raw materials
Raw materials
Preparation Products
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