(3S,5S)-Atorvastatin (sodium salt)
- Product Name
- (3S,5S)-Atorvastatin (sodium salt)
- CAS No.
- 1428118-38-0
- Chemical Name
- (3S,5S)-Atorvastatin (sodium salt)
- Synonyms
- Atorvastatin EP Impurity E Sodium Salt;Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Sal;Atorvastatin impurity 32/(3S,5S)-Atorvastatin Sodium Salt/Atorvastatin EP Impurity E Sodium Salt/(3S,5S)-Atorvastatin Calcium Salt/((3S,5S)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate) Sodium Salt
- CBNumber
- CB93152420
- Molecular Formula
- C33H36FN2NaO5
- Formula Weight
- 582.65
- MOL File
- 1428118-38-0.mol
(3S,5S)-Atorvastatin (sodium salt) Property
- storage temp.
- Store at -20°C
- solubility
- ≤0.5mg/ml in ethanol;15mg/ml in DMSO;25mg/ml in dimethyl formamide
- form
- crystalline solid
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18465
- Product name
- (3S,5S)-Atorvastatin (sodium salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 18465
- Product name
- (3S,5S)-Atorvastatin (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $330
- Updated
- 2024/03/01
- Product number
- 18465
- Product name
- (3S,5S)-Atorvastatin (sodium salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $583
- Updated
- 2024/03/01
- Product number
- A791735
- Product name
- (3S,5S)-AtorvastatinSodiumSalt
- Packaging
- 10mg
- Price
- $590
- Updated
- 2021/12/16
- Product number
- C4030
- Product name
- (3S,5S)-Atorvastatin(sodiumsalt)
- Packaging
- 10mg
- Price
- $666
- Updated
- 2021/12/16
(3S,5S)-Atorvastatin (sodium salt) Chemical Properties,Usage,Production
Uses
(3S,5S)-Atorvastatin Sodium Salt (Atorvastatin EP Impurity E) is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Biological Activity
atorvastatin exists in four optical forms. the (3r, 5r)-atorvastatin enantiomer displays the greatest activity against hmg-coa reductase. (3s,5s)-atorvastatin is an enantiomer of atorvastatin with little or no inhibitory activity against hmg-coa reductase [1]. atorvastatin is a synthetic hmg-coa reductase inhibitor implicated in lowering plasma cholesterol levels by inhibiting endogenous cholesterol synthesis. atorvastatin also reduces triglyceride levels through an as yet unproven mechanism [2]. in various trials in patients with hypercholesterolaemia, atorvastatin produced greater reductions in total cholesterol, apolipoprotein b, ldl-cholesterol and triglyceride levels. in patients with primary hypercholesterolaemia, atorvastatin in combination with colestipol produced significant reductions in ldl-cholesterol levels and smaller reductions in triglyceride levels than atorvastatin monotherapy [2].
References
[1] kocarek t a, dahn m s, cai h, et al. regulation of cyp2b6 and cyp3a expression by hydroxymethylglutaryl coenzyme a inhibitors in primary cultured human hepatocytes[j]. drug metabolism and disposition, 2002, 30(12): 1400-1405.
[2] lea a p, mctavish d. atorvastatin[j]. drugs, 1997, 53(5): 828-847.
(3S,5S)-Atorvastatin (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
(3S,5S)-Atorvastatin (sodium salt) Suppliers
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