GSK106 (hydrochloride)
- Product Name
- GSK106 (hydrochloride)
- CAS No.
- 1652591-82-6
- Chemical Name
- GSK106 (hydrochloride)
- Synonyms
- GSK106;GSK106 (hydrochloride);(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride
- CBNumber
- CB93152622
- Molecular Formula
- C24H28ClN5O
- Formula Weight
- 437.965
- MOL File
- 1652591-82-6.mol
GSK106 (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- 17490
- Product name
- GSK106 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 17490
- Product name
- GSK106 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 17490
- Product name
- GSK106 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 17490
- Product name
- GSK106 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $494
- Updated
- 2024/03/01
- Product number
- G797390
- Product name
- (3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanoneHydrochloride
- Packaging
- 5mg
- Price
- $235
- Updated
- 2021/12/16
GSK106 (hydrochloride) Chemical Properties,Usage,Production
Description
Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 . It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC50s > 100 μM). See the Structural Genomics Consortium (SGC) website for more information on both GSK484 and GSK106.
Uses
(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride is structurally similar to (3-Amino-1-piperidinyl)[1-methyl-2-(1-methyl-1H-indol-2-yl)-1H-benzimidazol-5-yl]-methanone TFA Salt (G797395) and is suitable to use as a control to identify inhibitors for protein arginine deiminase 4 (PAD4).
GSK106 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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