ChemicalBook > CAS DataBase List > 4-BROMO-1-PHENYL-1H-PYRAZOLE

4-BROMO-1-PHENYL-1H-PYRAZOLE

Product Name
4-BROMO-1-PHENYL-1H-PYRAZOLE
CAS No.
15115-52-3
Chemical Name
4-BROMO-1-PHENYL-1H-PYRAZOLE
Synonyms
4-bromo-1-phenylpyrazole;4-BROMO-1-PHENYL-1H-PYRAZOLE;1H-Pyrazole, 4-bromo-1-phenyl-;4-Bromo-1-phenyl-1H-pyrazole 98%
CBNumber
CB9315598
Molecular Formula
C9H7BrN2
Formula Weight
223.07
MOL File
15115-52-3.mol
More
Less

4-BROMO-1-PHENYL-1H-PYRAZOLE Property

Melting point:
78-79 °C
Boiling point:
296.2±13.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
solid
pka
-1.34±0.10(Predicted)
color 
Brown
More
Less

Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933199090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B687900
Product name
4-Bromo-1-phenylpyrazole
Packaging
500mg
Price
$85
Updated
2021/12/16
TRC
Product number
B687900
Product name
4-Bromo-1-phenylpyrazole
Packaging
5g
Price
$415
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139496
Product name
4-Bromo-1-phenyl-1H-pyrazole
Packaging
25g
Price
$662
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0012870
Product name
4-BROMO-1-PHENYL-1H-PYRAZOLE
Purity
95.00%
Packaging
1G
Price
$752.14
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139496
Product name
4-Bromo-1-phenyl-1H-pyrazole
Packaging
5G
Price
$190
Updated
2021/12/16
More
Less

4-BROMO-1-PHENYL-1H-PYRAZOLE Chemical Properties,Usage,Production

Uses

4-Bromo-1-phenylpyrazole is used to prepare canagliflozin aryl C-glucoside with thiophene ring as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

Synthesis

1126-00-7

15115-52-3

Example 29A Synthesis of 4-bromo-1-phenyl-1H-pyrazole: 1-phenylpyrazole (Aldrich, 1 g, 6.94 mmol) was dissolved in 10 mL of acetic acid, followed by the addition of 1.1 g of bromine (Fisher, 6.94 mmol) to a 10 mL solution of acetic acid. The reaction mixture was transferred to a pressure tube and the reaction was heated at 100 °C for 8 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was slowly poured into a 500 mL beaker containing ice and water and saturated aqueous NaHCO3 solution was added dropwise until the acetic acid was completely neutralized. The organic layer was separated by adding 50 mL of ethyl acetate (EtOAc) for extraction. The aqueous layer was then extracted with 2 x 15 mL of ethyl acetate, the organic phases were combined and dried with anhydrous Na2SO4. The organic phase was concentrated under reduced pressure to obtain the crude product. Purification by fast column chromatography (silica gel, 5:0 to 5:5 gradient elution of hexane-ethyl acetate) afforded 1.5 g of the target compound 4-bromo-1-phenyl-1H-pyrazole (6.72 mmol, 97% yield). Mass spectrum (DCI/NH3) m/z 223,225 (M+H)+.

References

[1] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[2] Patent: US2005/65178, 2005, A1. Location in patent: Page/Page column 31
[3] Patent: US2005/101602, 2005, A1. Location in patent: Page/Page column 68
[4] RSC Advances, 2016, vol. 6, # 93, p. 90031 - 90034
[5] Tetrahedron Letters, 2007, vol. 48, # 26, p. 4595 - 4599

4-BROMO-1-PHENYL-1H-PYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-BROMO-1-PHENYL-1H-PYRAZOLE Suppliers

China 102 India 1 Russia 1 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 12 Global 120
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
China Langchem Inc.
Tel
021-58956006,021-58950017 15800617331
Fax
021-58956100
Email
sales@langchem.com
Country
China
ProdList
222
Advantage
57
Acorn PharmaTech Co., Ltd.
Tel
025-58395930
Fax
025-5861-9182
Email
sales@acornpharma.com
Country
China
ProdList
982
Advantage
60
More
Less

View Lastest Price from 4-BROMO-1-PHENYL-1H-PYRAZOLE manufacturers

Career Henan Chemical Co
Product
4-BROMO-1-PHENYL-1H-PYRAZOLE 15115-52-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

15115-52-3, 4-BROMO-1-PHENYL-1H-PYRAZOLERelated Search:

4-BROMO-1-PHENYL-1H-PYRAZOLE 4-BROMO-5-METHYL-1-PHENYL-1H-PYRAZOLE 5-Amino-4-bromo-3-phenyl-1H-pyrazole,5-Amino-4-bromo-3-phenyl-1H-pyrazole 95+%,3-Amino-4-bromo-5-phenyl-1H-pyrazole, 96% 1-[4-(BROMOMETHYL)PHENYL]-1H-PYRAZOLE 4-BROMO-3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE 3,4,5-TRIBROMO-1-(4-NITROPHENYL)-1H-PYRAZOLE 4-BROMO-3-PHENYL-1H-PYRAZOLE 4-BROMO-5-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE N-ALLYL-4-BROMO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-5-CARBOXAMIDE 2-([4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINO]METHYLIDENE)MALONONITRILE 4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINE N-(2-FLUOROBENZOYL)-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA DIETHYL 2-([4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)ANILINO]METHYLIDENE)MALONATE N-(4-CHLOROPHENYL)-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA N-(2,6-DICHLOROBENZOYL)-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]UREA N1-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]-4-CHLOROBENZAMIDE N1-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]-4-CHLOROBENZENE-1-SULFONAMIDE N,N-DIMETHYL-N'-[4-(3,4,5-TRIBROMO-1H-PYRAZOL-1-YL)PHENYL]IMINOFORMAMIDE

  • 4-BROMO-1-PHENYL-1H-PYRAZOLE
  • 4-Bromo-1-phenyl-1H-pyrazole 98%
  • 4-bromo-1-phenylpyrazole
  • 1H-Pyrazole, 4-bromo-1-phenyl-
  • 15115-52-3
  • Azoles
  • blocks
  • Bromides