4-BROMO-1-PHENYL-1H-PYRAZOLE
- Product Name
- 4-BROMO-1-PHENYL-1H-PYRAZOLE
- CAS No.
- 15115-52-3
- Chemical Name
- 4-BROMO-1-PHENYL-1H-PYRAZOLE
- Synonyms
- 4-bromo-1-phenylpyrazole;4-BROMO-1-PHENYL-1H-PYRAZOLE;1H-Pyrazole, 4-bromo-1-phenyl-;4-Bromo-1-phenyl-1H-pyrazole 98%
- CBNumber
- CB9315598
- Molecular Formula
- C9H7BrN2
- Formula Weight
- 223.07
- MOL File
- 15115-52-3.mol
4-BROMO-1-PHENYL-1H-PYRAZOLE Property
- Melting point:
- 78-79 °C
- Boiling point:
- 296.2±13.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- -1.34±0.10(Predicted)
- color
- Brown
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B687900
- Product name
- 4-Bromo-1-phenylpyrazole
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- B687900
- Product name
- 4-Bromo-1-phenylpyrazole
- Packaging
- 5g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- FB139496
- Product name
- 4-Bromo-1-phenyl-1H-pyrazole
- Packaging
- 25g
- Price
- $662
- Updated
- 2021/12/16
- Product number
- HCH0012870
- Product name
- 4-BROMO-1-PHENYL-1H-PYRAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $752.14
- Updated
- 2021/12/16
- Product number
- FB139496
- Product name
- 4-Bromo-1-phenyl-1H-pyrazole
- Packaging
- 5G
- Price
- $190
- Updated
- 2021/12/16
4-BROMO-1-PHENYL-1H-PYRAZOLE Chemical Properties,Usage,Production
Uses
4-Bromo-1-phenylpyrazole is used to prepare canagliflozin aryl C-glucoside with thiophene ring as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.
Synthesis
1126-00-7
15115-52-3
Example 29A Synthesis of 4-bromo-1-phenyl-1H-pyrazole: 1-phenylpyrazole (Aldrich, 1 g, 6.94 mmol) was dissolved in 10 mL of acetic acid, followed by the addition of 1.1 g of bromine (Fisher, 6.94 mmol) to a 10 mL solution of acetic acid. The reaction mixture was transferred to a pressure tube and the reaction was heated at 100 °C for 8 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was slowly poured into a 500 mL beaker containing ice and water and saturated aqueous NaHCO3 solution was added dropwise until the acetic acid was completely neutralized. The organic layer was separated by adding 50 mL of ethyl acetate (EtOAc) for extraction. The aqueous layer was then extracted with 2 x 15 mL of ethyl acetate, the organic phases were combined and dried with anhydrous Na2SO4. The organic phase was concentrated under reduced pressure to obtain the crude product. Purification by fast column chromatography (silica gel, 5:0 to 5:5 gradient elution of hexane-ethyl acetate) afforded 1.5 g of the target compound 4-bromo-1-phenyl-1H-pyrazole (6.72 mmol, 97% yield). Mass spectrum (DCI/NH3) m/z 223,225 (M+H)+.
References
[1] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[2] Patent: US2005/65178, 2005, A1. Location in patent: Page/Page column 31
[3] Patent: US2005/101602, 2005, A1. Location in patent: Page/Page column 68
[4] RSC Advances, 2016, vol. 6, # 93, p. 90031 - 90034
[5] Tetrahedron Letters, 2007, vol. 48, # 26, p. 4595 - 4599
4-BROMO-1-PHENYL-1H-PYRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-1-PHENYL-1H-PYRAZOLE Suppliers
- Tel
- --
- Fax
- --
- asinex@asinex.com
- Country
- Russia
- ProdList
- 6615
- Advantage
- 66
View Lastest Price from 4-BROMO-1-PHENYL-1H-PYRAZOLE manufacturers
- Product
- 4-BROMO-1-PHENYL-1H-PYRAZOLE 15115-52-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31