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EED226

Product Name
EED226
CAS No.
2083627-02-3
Chemical Name
EED226
Synonyms
EED226;CS-2549;EED226 ，S8496;EED226;EED 226;EED 226 monohydrate;EED226;EED 226;MAK683;EED226, 10 mM in DMSO;MAK683(EED226/Compound 43);1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-;N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
CBNumber
CB93164715
Molecular Formula
C17H15N5O3S
Formula Weight
369.4
MOL File
2083627-02-3.mol
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EED226 Property

Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
-20°
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
solid
pka
1.19±0.30(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
25mg
Price
$573
Updated
2024/03/01
TRC
Product number
E338000
Product name
EED226
Packaging
5mg
Price
$275
Updated
2021/12/16
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EED226 Chemical Properties,Usage,Production

Description

EED-226 (2083627-02-3) is a potent (IC50= 23.4 nM) and selective allosteric inhibitor of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).It caused drastic proliferation inhibition in lymphoma cells with EZH2 mutations and caused shrinkage and slower tumor growth in mice using a subcutaneous xenograft model of Karpas422.

Uses

EED 226 is a potent, selective and orally bioavailable EED inhibitor, inducing robust and sustained tumor regression in specific models. Effective PRC2 inhibitorin the treatment of PRC2-dependant cancers.

in vivo

EED226 induces robust and sustained tumor regression in EZH2MUT pre-clinical DLBCL model. In CD-1 mice, dosing of EED226 for 14 days at 300 mg/kg bid is well tolerated with no apparent adverse effects. It has very low in vivo clearance, and approximately 100% oral bioavailability. EED226 has low volume of distribution (0.8 L/kg), reasonable terminal t1/2 (2.2 h), and moderate plasma protein binding (PPB)[2].

storage

Store at -20°C

References

[1] YING HUANG*. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy[J]. Journal of Medicinal Chemistry, 2017, 60 6: 2215-2226. DOI:10.1021/acs.jmedchem.6b01576
[2] WEI QI. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED[J]. Nature chemical biology, 2017, 13 4: 381-388. DOI:10.1038/nchembio.2304

EED226 Preparation Products And Raw materials

Raw materials

Preparation Products

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EED226 Suppliers

China 91 India 1 United States 11 Global 103
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
NanJing Xienuo bio Co.,Ltd.
Tel
025-84112752 13805181430
Fax
+86-25-84846489
Email
154301870@qq.com
Country
China
ProdList
1000
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68

2083627-02-3, EED226Related Search:

AG 490 Brefeldin A Ko 143 ZM 336372

  • EED226
  • N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
  • MAK683(EED226/Compound 43)
  • CS-2549
  • EED226;EED 226
  • EED226;EED 226;MAK683
  • 1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-
  • N-[(furan-2-yl)methyl]-8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
  • EED226, 10 mM in DMSO
  • EED 226 monohydrate
  • EED226 ，S8496
  • 2083627-02-3