ChemicalBook > CAS DataBase List > EED226

EED226

Product Name
EED226
CAS No.
2083627-02-3
Chemical Name
EED226
Synonyms
EED226;CS-2549;EED226 ，S8496;EED226;EED 226;EED 226 monohydrate;EED226;EED 226;MAK683;EED226, 10 mM in DMSO;MAK683(EED226/Compound 43);1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-;N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
CBNumber
CB93164715
Molecular Formula
C17H15N5O3S
Formula Weight
369.4
MOL File
2083627-02-3.mol
More
Less

EED226 Property

Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
-20°
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
solid
pka
1.19±0.30(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
22031
Product name
EED226
Purity
≥99%
Packaging
25mg
Price
$573
Updated
2024/03/01
TRC
Product number
E338000
Product name
EED226
Packaging
1mg
Price
$70
Updated
2021/12/16
More
Less

EED226 Chemical Properties,Usage,Production

Description

EED-226 (2083627-02-3) is a potent (IC50= 23.4 nM) and selective allosteric inhibitor of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).It caused drastic proliferation inhibition in lymphoma cells with EZH2 mutations and caused shrinkage and slower tumor growth in mice using a subcutaneous xenograft model of Karpas422.

Uses

EED 226 is a potent, selective and orally bioavailable EED inhibitor, inducing robust and sustained tumor regression in specific models. Effective PRC2 inhibitorin the treatment of PRC2-dependant cancers.

in vivo

EED226 induces robust and sustained tumor regression in EZH2MUT pre-clinical DLBCL model. In CD-1 mice, dosing of EED226 for 14 days at 300 mg/kg bid is well tolerated with no apparent adverse effects. It has very low in vivo clearance, and approximately 100% oral bioavailability. EED226 has low volume of distribution (0.8 L/kg), reasonable terminal t1/2 (2.2 h), and moderate plasma protein binding (PPB)[2].

storage

Store at -20°C

References

[1] YING HUANG*. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy[J]. Journal of Medicinal Chemistry, 2017, 60 6: 2215-2226. DOI:10.1021/acs.jmedchem.6b01576
[2] WEI QI. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED[J]. Nature chemical biology, 2017, 13 4: 381-388. DOI:10.1038/nchembio.2304

EED226 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

EED226 Suppliers

China 91 India 1 United States 11 Global 103
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58

2083627-02-3, EED226Related Search:

AG 490 Brefeldin A Ko 143 ZM 336372

  • EED226
  • N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
  • MAK683(EED226/Compound 43)
  • CS-2549
  • EED226;EED 226
  • EED226;EED 226;MAK683
  • 1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-(2-furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-
  • N-[(furan-2-yl)methyl]-8-(4-methanesulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
  • EED226, 10 mM in DMSO
  • EED 226 monohydrate
  • EED226 ，S8496
  • 2083627-02-3