LGD-6972

Product Name: LGD-6972
CAS No.: 1207989-09-0
Chemical Name: LGD-6972
Synonyms: LGD-6972;LGD6972; LGD 6972;LGD 6972,LGD-6972,LGD6972,Inhibitor,hyperglycaemia,GCGR,Diabetes,cAMP,glucagon,inhibit,Glucagon Receptor;(R)-2-(4-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-4-yl)-3-oxo-3-((2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)amino)propyl)benzamido)ethane-1-sulfonic acid;2-({4-[(2R)-2-{4'-tert-butyl-[1,1'-biphenyl]-4-yl}-2-({2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl}carbamoyl)ethyl]phenyl}formamido)ethane-1-sulfonic acid;Ethanesulfonic acid, 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]benzoyl]amino]-
CBNumber: CB93171696
Molecular Formula: C43H46N2O5S
Formula Weight: 702.9
MOL File: 1207989-09-0.mol

More

Less

LGD-6972 Property

Density: 1.206±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:125.0(Max Conc. mg/mL);177.83(Max Conc. mM)
form: Solid
pka: 1.36±0.50(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 10mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 50mg
Price: $2220
Updated: 2021/12/16

ChemScene

Product number: CS-6449
Product name: LGD-6972
Purity: >98.0%
Packaging: 100mg
Price: $3300
Updated: 2021/12/16

More

Less

LGD-6972 Chemical Properties,Usage,Production

Uses

LGD-6972 is a selective and orally active glucagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research[1].

in vivo

In vivo, LGD-6972 reduces acute glucagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting glucagon receptor signaling^[1].

References

[1] Vajda EG, et al. Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2017 Jan;19(1):24-32. DOI:10.1111/dom.12752

LGD-6972 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LGD-6972 Suppliers

China 26 United States 4 Global 30

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

1207989-09-0, LGD-6972Related Search:

LGD6972; LGD 6972

LGD-6972

Ethanesulfonic acid, 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]benzoyl]amino]-

LGD 6972,LGD-6972,LGD6972,Inhibitor,hyperglycaemia,GCGR,Diabetes,cAMP,glucagon,inhibit,Glucagon Receptor

2-({4-[(2R)-2-{4'-tert-butyl-[1,1'-biphenyl]-4-yl}-2-({2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl}carbamoyl)ethyl]phenyl}formamido)ethane-1-sulfonic acid

(R)-2-(4-(2-(4'-(tert-butyl)-[1,1'-biphenyl]-4-yl)-3-oxo-3-((2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl)amino)propyl)benzamido)ethane-1-sulfonic acid

1207989-09-0

C43H46N2O5S