ChemicalBook > CAS DataBase List > DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
- Product Name
- DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
- CAS No.
- 64005-90-9
- Chemical Name
- DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
- Synonyms
- PIB;PiB >=98% (HPLC);WNKQGFNIIHNGQM-UHFFFAOYSA-N;PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem;DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE;PPIase-Parvulin inhibitor,Inhibitor,PPIase Parvulin Inhibitor,PPIaseParvulin Inhibitor,inhibit;diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate;Benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, 2,7-diethyl ester
- CBNumber
- CB9321371
- Molecular Formula
- C22H18N2O8
- Formula Weight
- 438.39
- MOL File
- Mol file
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DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble1-2mg/mL (warmed)
- form
- Brownish solid
- color
- white to light brown
- InChI
- InChI=1S/C18H18N2O8/c1-3-23-15(21)9-19-25-11-5-7-13-18-14(8-6-12(26-19)17(11)18)28-20(27-13)10-16(22)24-4-2/h5-8H,3-4,9-10H2,1-2H3
- InChIKey
- RUZSTTGSEVILES-UHFFFAOYSA-N
- SMILES
- C12=CC=C3C4C1=C(C=CC=4ON(CC(OCC)=O)O3)ON(CC(OCC)=O)O2
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- B7688
- Product name
- PiB
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $103
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 17214
- Product name
- PPIase-Parvulin Inhibitor
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17214
- Product name
- PPIase-Parvulin Inhibitor
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- B7688
- Product name
- PiB
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $332
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 17214
- Product name
- PPIase-Parvulin Inhibitor
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $211
- Updated
- 2024/03/01
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DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Chemical Properties,Usage,Production
Uses
PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 μM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs)[1].
Biological Activity
PiB is an inhibitor of the peptidylprolyl isomerase Pin-1. Inhibition of Pin-1 leads to destabilization of the transcription factor Nanog, which is required for maintenance of embryonic stem cell cultures.
References
[1] Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24. DOI:10.1016/s1074-5521(02)00310-1
DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
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DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Suppliers
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