Butanedioic acid, methylene-, 4-octyl ester

ChemicalBook > CAS DataBase List > Butanedioic acid, methylene-, 4-octyl ester

Butanedioic acid, methylene-, 4-octyl ester

Product Name: Butanedioic acid, methylene-, 4-octyl ester
CAS No.: 3133-16-2
Chemical Name: Butanedioic acid, methylene-, 4-octyl ester
Synonyms: Itaconate;4-Octyl itaconate;Monooctyl Itaconate;itaconate(CTK1B2911);4-Octyl itaconate(CTK1B2911);4-Octyl itaconate >=98% (HPLC);4-Octyl itaconate, 10 mM in DMSO;2-Methylenebutanedioic acid 4-octyl ester;Butanedioic acid, methylene-, 4-octyl ester;2-Methylene-4-(octyloxy)-4-oxobutanoic acid
CBNumber: CB93223447
Molecular Formula: C13H22O4
Formula Weight: 242.32
MOL File: 3133-16-2.mol

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Butanedioic acid, methylene-, 4-octyl ester Property

Boiling point:: 377.2±25.0 °C(Predicted)
Density: 1.026±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form: A crystalline solid
pka: 3.84±0.11(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25374
Product name: 4-octyl Itaconate
Purity: ≥98% (mixture of tautomers)
Packaging: 50mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 25374
Product name: 4-octyl Itaconate
Purity: ≥98% (mixture of tautomers)
Packaging: 100mg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 25374
Product name: 4-octyl Itaconate
Packaging: 25mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 25374
Product name: 4-octyl Itaconate
Purity: ≥98% (mixture of tautomers)
Packaging: 250mg
Price: $292
Updated: 2024/03/01

Tocris

Product number: 6662
Product name: 4-Octylitaconate
Purity: ≥98%(HPLC)
Packaging: 50
Price: $225
Updated: 2021/12/16

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Butanedioic acid, methylene-, 4-octyl ester Chemical Properties,Usage,Production

Uses

4-Octyl Itaconate increases nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.

Biological Activity

4-Octyl itaconate (4-OI) possesses anti-inflammatory effects. It can obstruct glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and glycolysis in macrophages. It can be a good substitute to itaconate due to its thiol reactivity. The electrophilic α and β-unsaturated moieties of 4-OI might help to alkylate the thiol in cysteine residues of proteins through Michael reaction.', 'The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function. 4-Octyl itaconate is a cell-permeable itaconate derivative th at decreases cytokine production and is protective against lipopolysaccharide-induced lethality in vivo. Esterases in mouse myoblast cells and macrophages hydrolyze it to itaconate, which alkylates cysteine residues on KEAP1, allowing the transcription factor Nrf2 to increase the expression of anti-oxidant and anti-inflammatory downstream genes.

storage

Store at -20°C

Butanedioic acid, methylene-, 4-octyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Butanedioic acid, methylene-, 4-octyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Butanedioic acid, methylene-, 4-octyl ester 3133-16-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-07

Career Henan Chemical Co

Product: Butanedioic acid, methylene-, 4-octyl ester 3133-16-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

3133-16-2, Butanedioic acid, methylene-, 4-octyl esterRelated Search:

Cupric acetate monohydrate Maleic acid Fumaric acid Acrylic acid Adipic acid Sebacic acid Itaconic acid

Butanedioic acid, methylene-, 4-octyl ester

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3133-16-2

C13H21O4