O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE Property

Melting point:

62-65 °C (lit.)

Boiling point:

87-90 °C/40 mmHg (lit.)

Density 

0.849±0.06 g/cm3(Predicted)

Flash point:

54°C

storage temp. 

2-8°C

solubility 

freely sol hexane, chloroform, and most organic solvents; insol water.

pka

4.75±0.70(Predicted)

form 

solid

Water Solubility 

Hydrolyzes in water.

Hydrolytic Sensitivity

7: reacts slowly with moisture/water

Sensitive 

Moisture Sensitive

BRN 

2424306

CAS DataBase Reference

41879-39-4(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN 3259 8/PG 2

WGK Germany 

3

F 

10-21

TSCA 

No

HazardClass 

8

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

O-(TERT-BUTYLDIMETHYLSILYL)HYDROXYLAMINE Chemical Properties,Usage,Production

Physical properties

mp 62–65°C; bp 87–90°C/40 mmHg.

Uses

O-(tert-Butyldimethylsilyl)hydroxylamine (tert-butyldimethylsilyl-O-hydroxylamine)is used to induce the cleavage, during solid supported synthesis of hydroxamic acids. It also finds it uses as a chemical additive and an intermediate.

Uses

O-(tert-Butyldimethylsilyl)hydroxylamine (tert-butyldimethylsilyl-O-hydroxylamine) may be used to induce the cleavage, during solid supported synthesis of hydroxamic acids.

Preparation

the reagents are most conveniently prepared by treatment of hydroxylamine hydrochloride with ethylenediamine in dichloromethane, followed by the appropriate chlorosilane.A two-step procedure using ammonia in place of ethylenediamine has also been reported.