ChemicalBook > CAS DataBase List > 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE

Product Name
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
CAS No.
112192-04-8
Chemical Name
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
Synonyms
Roxindole;RoxindoleHCl;Roxindole [inn];ROXINDOLE HYDROCHLORIDE;1H-Indol-5-ol, 3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-;3-[4-[(3,6-Dihydro-4-phenylpyridin)-1(2H)-yl]butyl]-1H-indol-5-ol;3-[4-(3,6-Dihydro-4-phenylpyridine-1(2H)-yl)butyl]-1H-indole-5-ol;3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
CBNumber
CB9330973
Molecular Formula
C23H26N2O
Formula Weight
346.47
MOL File
112192-04-8.mol
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3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Property

Melting point:
>165°C (dec.)
Boiling point:
575.7±50.0 °C(Predicted)
Density 
1.173±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
DMSO (Slightly), Water (Slightly)
pka
10.15±0.40(Predicted)
form 
Solid
color 
Pale Beige to Light Beige
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1559
Product name
Roxindolehydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$181
Updated
2021/12/16
Tocris
Product number
1559
Product name
Roxindolehydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$738
Updated
2021/12/16
Usbiological
Product number
256504
Product name
Roxindole hydrochloride
Packaging
10mg
Price
$423
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012443
Product name
ROXINDOLE
Purity
95.00%
Packaging
5MG
Price
$503.71
Updated
2021/12/16
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3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Roxindole Hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist.

Definition

ChEBI: Roxindole is a member of indoles. It has a role as an alpha-adrenergic antagonist and a serotonergic drug.

Biological Activity

Dopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .

in vivo

Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[1].
Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3].

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE Suppliers

China 14 Europe 1 Germany 3 United Kingdom 1 United States 4 Global 23
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
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info@emmx.com
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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Career Henan Chemica Co
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0371-86658258
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laboratory@coreychem.com
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Energy Chemical
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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China
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Santa Cruz Biotechnology Inc
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021-60936350
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scbt@scbt.com
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China
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DAYANG CHEM (HANGZHOU) CO.,LTD
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+86-88938639 +86-17705817739
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info@dycnchem.com
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China
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53899
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Aladdin Scientific
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tp@aladdinsci.com
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United States
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52923
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112192-04-8, 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDERelated Search:

ROXINDOLE MESYLATE 3-(4-(4-PHENYL-1,2,3,6-TETRAHYDRO-1-PYRIDYL)BUTYL)INDOLE, HCL 1,2,3,6-Tetrahydro-4-phenyl-pyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

  • 3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE
  • ROXINDOLE HYDROCHLORIDE
  • Roxindole
  • RoxindoleHCl
  • 3-[4-(3,6-Dihydro-4-phenylpyridine-1(2H)-yl)butyl]-1H-indole-5-ol
  • 3-[4-[(3,6-Dihydro-4-phenylpyridin)-1(2H)-yl]butyl]-1H-indol-5-ol
  • Roxindole [inn]
  • 1H-Indol-5-ol, 3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-
  • 112192-04-8
  • Dopamine receptor