1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Product Name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
CAS No.: 23007-85-4
Chemical Name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Synonyms: MPTP;MPTP HCl;MPTP HYDROCHLORIDE;0MPTP hydrochloride;Methyl Hydrochloride;23007-85-4/28289-54-5;NSC 139654 Hydrochloride;Pethidine EP Impurity B HCl;1-METHYL-4-PHENYL-1 2 3 6-TETRAHYDROPYR&;1-methyl-4-phenyl-3,6-dihydro-2H-pyridine
CBNumber: CB0133791
Molecular Formula: C12H16ClN
Formula Weight: 209.72
MOL File: 23007-85-4.mol

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Property

Melting point:: 249.0 to 254.0 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: White solid
color: white to off-white
BRN: 3707312
Stability:: Light Sensitive
InChI: InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChIKey: KOWJANGMTAZWDT-UHFFFAOYSA-N
SMILES: C1(=CCN(C)CC1)C1C=CC=CC=1.Cl
CAS DataBase Reference: 23007-85-4

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Safety

Hazard Codes: T
Risk Statements: 25-39/23/24/25-36/37/38
Safety Statements: 45-39-26
RIDADR: 2811
WGK Germany: 3
RTECS: UT8358950
HS Code: 2933.39.9200
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M0896
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Purity: powder
Packaging: 10mg
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: M0896
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Purity: powder
Packaging: 100mg
Price: $394
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.06382
Product name: MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem
Packaging: 10mg
Price: $182
Updated: 2024/03/01

TCI Chemical

Product number: M2690
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $82
Updated: 2024/03/01

TCI Chemical

Product number: M2690
Product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $241
Updated: 2024/03/01

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Uses

MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.[Cayman Chemical]

Biochem/physiol Actions

Dopaminergic neurotoxin.

Purification Methods

Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]

References

[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.
[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Suppliers

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View Lastest Price from 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 23007-85-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-28

Career Henan Chemical Co

Product: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 23007-85-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

23007-85-4, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochlorideRelated Search:

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MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem

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1-methyl-4-phenyl-1,2,3,6-tetra-*hydropyridine hy

1-METHYL-4-PHENYL-1 2 3 6-TETRAHYDROPYR&

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride,MPTP hydrochloride

1- Methyl-4-phenyl -1,2,3,6-four hydrogen pyridinehydrochloride

NSC 139654 Hydrochloride

Methyl Hydrochloride

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride &gt

MPTP HCl

23007-85-4/28289-54-5

1,2,3,6-tetrahydro-1-methyl-4-phenyl-Pyridine hydrochloride (1:1)

Pethidine EP Impurity B HCl

0MPTP hydrochloride

1-methyl-4-phenyl-3,6-dihydro-2H-pyridine

MPTP : 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

23007-85-4

C12H15NHCl

Heterocyclic Compounds

Neurochemicals