3-Pyridylacetic acid hydrochloride
- Product Name
- 3-Pyridylacetic acid hydrochloride
- CAS No.
- 6419-36-9
- Chemical Name
- 3-Pyridylacetic acid hydrochloride
- Synonyms
- 3-PYRIDYLACETIC ACID HCL;2-(pyridin-3-yl)acetic acid hydrochloride;Lioxone Hydro;TIMTEC-BB SBB003812;Nicotine Impurity 3;3-pyridylessigsaeure;Coletin Hydrochloride;Risedronate Impurity D;Lessterol Hydrochloride;3-PYRIDYLACETIC ACID HCI
- CBNumber
- CB2349253
- Molecular Formula
- C7H8ClNO2
- Formula Weight
- 173.6
- MOL File
- 6419-36-9.mol
3-Pyridylacetic acid hydrochloride Property
- Melting point:
- 161-163 °C(lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Crystalline Powder, Crystals and/or Chunks
- color
- White to light yellow or beige
- Merck
- 14,7971
- BRN
- 3696630
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C7H7NO2.ClH/c9-7(10)4-6-2-1-3-8-5-6;/h1-3,5H,4H2,(H,9,10);1H
- InChIKey
- XVCCOEWNFXXUEV-UHFFFAOYSA-N
- SMILES
- C(C1=CN=CC=C1)C(=O)O.Cl
- CAS DataBase Reference
- 6419-36-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P65800
- Product name
- 3-Pyridylacetic acid hydrochloride
- Purity
- 98%
- Packaging
- 1g
- Price
- $27.6
- Updated
- 2025/07/31
- Product number
- P65800
- Product name
- 3-Pyridylacetic acid hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $40.2
- Updated
- 2025/07/31
- Product number
- PHR2079
- Product name
- Risedronate Impurity D
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 50 mg
- Price
- $575
- Updated
- 2025/07/31
- Product number
- P0639
- Product name
- 3-Pyridylacetic Acid Hydrochloride
- Purity
- >99.0%(T)
- Packaging
- 10g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- P0639
- Product name
- 3-Pyridylacetic Acid Hydrochloride
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $161
- Updated
- 2025/07/31
3-Pyridylacetic acid hydrochloride Chemical Properties,Usage,Production
Description
3-Pyridineacetic acid hydrochloride is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids).
Chemical Properties
white to beige crystalline powder
Uses
3-Pyridylacetic Acid is a metabolite of Nicotine (N412420). 3-Pyridylacetic Acid is an antilipemic.
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General Description
Risedronate Impurity D is an impurity of risedronate, which is a new generation pyridinyl bisphosphonate, effectively used in the treatment of Paget′s disease of bone. It is also used for the treatment of skeletal disorders since it inhibits osteoclast-mediated bone resorption and modulates bone metabolism.
Synthesis
61494-55-1
6419-36-9
The general procedure for synthesizing pyridine-3-acetic acid hydrochloride from 2-chloropyridine-3-acetic acid is as follows: 1. 50 grams of 2-chloro-3-pyridineacetic acid is prepared as 25% mass fraction of 2-chloro-3-pyridineacetic acid sodium solution. 2. 47 g of 30% sodium hydroxide solution (a small amount of insoluble polymer may be generated during the reaction) is added to the above solution, stirred well and filtered. 3. 20% of nickel ruanne catalyst is added to the filtrate, heated to 90-95°C, and the reaction is carried out by passing hydrogen gas at atmospheric pressure or 1MPa pressure. 4. After completion of the reaction, the catalyst is removed by filtration and the filtrate is adjusted to pH 4 with hydrochloric acid. 5. Activated carbon was added for decolorization and the solvent was subsequently removed to obtain a viscous liquid (containing NaCl crystals). 6. 100 g of anhydrous ethanol was added to the viscous liquid, which was fully dissolved and filtered to obtain an ethanol solution of 3-pyridylacetic acid. 7. Remove the ethanol in the solution (after drying to obtain a viscous liquid, can be appropriate amount of water and then dry again). 8. Add 50 g of water and 35 g of hydrochloric acid and react at 50 °C to form a salt, followed by drying to remove the solvent water to obtain a viscous solid. 9. Cooled to room temperature, washed with 50 g of anhydrous ethanol, filtered, rinsed with a small amount of ethanol solid, drying, to obtain 47.5 g of pyridine-3-acetic acid hydrochloride, purity 99.1%, yield 95.0%.
References
[1] Patent: CN106366034, 2017, A. Location in patent: Paragraph 0020; 0023; 0024; 0025; 0028; 0029
3-Pyridylacetic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Pyridylacetic acid hydrochloride manufacturers
- Product
- 3-Pyridylacetic acid hydrochloride 6419-36-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-25
- Product
- 3-Pyridylacetic acid hydrochloride 6419-36-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08
- Product
- 3-Pyridylacetic acid hydrochloride 6419-36-9
- Price
- US $1.00/KG
- Min. Order
- 25KG
- Purity
- 99.0%
- Supply Ability
- 5000KG/th
- Release date
- 2023-06-14