ChemicalBook > CAS DataBase List > 6-bromo-4-fluoro-1H-indazol-3-amine

6-bromo-4-fluoro-1H-indazol-3-amine

Product Name
6-bromo-4-fluoro-1H-indazol-3-amine
CAS No.
1227912-19-7
Chemical Name
6-bromo-4-fluoro-1H-indazol-3-amine
Synonyms
6-bromo-4-fluoro-1H-indazol-3-amine;6-bromo-4-fluoro-1H-indazol-4-amine;1H-Indazol-3-amine, 6-bromo-4-fluoro-;6-Bromo-4-fluoro-1H-indazol-3-ylamine
CBNumber
CB93334163
Molecular Formula
C7H5BrFN3
Formula Weight
230.04
MOL File
1227912-19-7.mol
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6-bromo-4-fluoro-1H-indazol-3-amine Property

storage temp. 
2-8°C(protect from light)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C7H5BrFN3/c8-3-1-4(9)6-5(2-3)11-12-7(6)10/h1-2H,(H3,10,11,12)
InChIKey
OLSISKHGQBVTEW-UHFFFAOYSA-N
SMILES
N1C2=C(C(F)=CC(Br)=C2)C(N)=N1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC201082
Product name
6-Bromo-4-fluoro-1H-indazol-3-amine
Purity
97%
Packaging
250mg
Price
$144
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-B-0D
Product name
6-Bromo-4-fluoro-1H-indazol-3-amine
Purity
97%
Packaging
100mg
Price
$144
Updated
2021/12/16
AK Scientific
Product number
0921DP
Product name
6-Bromo-4-fluoro-1H-indazol-3-amine
Packaging
100mg
Price
$196
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-B-0D
Product name
6-Bromo-4-fluoro-1H-indazol-3-amine
Purity
97%
Packaging
250mg
Price
$231
Updated
2021/12/16
Apolloscientific
Product number
PC201082
Product name
6-Bromo-4-fluoro-1H-indazol-3-amine
Purity
97%
Packaging
100mg
Price
$90
Updated
2021/12/16
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6-bromo-4-fluoro-1H-indazol-3-amine Chemical Properties,Usage,Production

Synthesis

123843-67-4

1227912-19-7

1. 4-Bromo-2,6-difluorobenzonitrile (i-9a) (30 g, 138 mmol) was dissolved in anhydrous ethanol (300 mL) under nitrogen protection. 2. Hydrazine hydrate (NH2NH2-H2O) (27.6 g, 552 mmol) was slowly added dropwise with stirring at room temperature. 3. The reaction mixture was degassed, then heated to 90 °C and stirred to react for 2 hours. 4. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with acetone (180 mL) and allowed to stand overnight. 5. The precipitated solid was collected by filtration and washed with dichloromethane (DCM) to afford the target compound, 6-bromo-4-fluoro-1H-indazol-3-amine (i-9b) (30 g, 94% yield), as a white solid. 6. The molecular ions were analyzed by LCMS (ESI), measuring the peak [M+H]+ was 230, which was consistent with the theoretically calculated value of C7H5BrFN3 .

References

[1] Patent: WO2014/28591, 2014, A2. Location in patent: Page/Page column 50
[2] Patent: US2015/210687, 2015, A1. Location in patent: Paragraph 0261
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3782 - 3786

6-bromo-4-fluoro-1H-indazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-bromo-4-fluoro-1H-indazol-3-amine Suppliers

China 28 India 1 United States 2 Global 31
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1227912-19-7, 6-bromo-4-fluoro-1H-indazol-3-amineRelated Search:

6-BROMO-4-CHLORO-3-IODO (1H)INDAZOLE

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  • 6-Bromo-4-fluoro-1H-indazol-3-ylamine
  • 1H-Indazol-3-amine, 6-bromo-4-fluoro-
  • 6-bromo-4-fluoro-1H-indazol-4-amine
  • 1227912-19-7