2'-O,4'-C-Methylenecytidine
- Product Name
- 2'-O,4'-C-Methylenecytidine
- CAS No.
- 206055-69-8
- Chemical Name
- 2'-O,4'-C-Methylenecytidine
- Synonyms
- 2'-O,4'-C-Methylenecytidine;Cytidine, 2'-O,4'-C-methylene-;2’-O,4’-C-Methylenecytidine, LNA-C;4-Amino-1-((1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidin-2(1H)-one
- CBNumber
- CB93334224
- Molecular Formula
- C10H13N3O5
- Formula Weight
- 255.23
- MOL File
- 206055-69-8.mol
2'-O,4'-C-Methylenecytidine Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
2'-O,4'-C-Methylenecytidine Chemical Properties,Usage,Production
Uses
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands[1][2].
Biological Activity
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands[1][2].
References
[1]. bicyclic nucleoside analogue, N-type conformation, synthesize oligonucleotides, duplexes [2]. Obika S, et, al. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides. Tetrahedron Letters. 1998 Jul 23; 39(30):5401-04.
2'-O,4'-C-Methylenecytidine Preparation Products And Raw materials
Raw materials
Preparation Products
2'-O,4'-C-Methylenecytidine Suppliers
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