Pseudocoptisine chloride
- Product Name
- Pseudocoptisine chloride
- CAS No.
- 30044-78-1
- Chemical Name
- Pseudocoptisine chloride
- Synonyms
- Isocoptisine chloride;Pseudocoptisine chloride;Isocoptisine,anti-amnestic,Pseudocoptisine chloride,cytokines,anti-inflammatory,Pseudocoptisine,pro-inflammatory,RAW 264.7,Cholinesterase (ChE),inhibit,Inhibitor
- CBNumber
- CB93340603
- Molecular Formula
- C19H14ClNO4
- Formula Weight
- 355.77
- MOL File
- 30044-78-1.mol
Pseudocoptisine chloride Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- Yellow to brown
N-Bromosuccinimide Price
- Product number
- CS-0158969
- Product name
- Pseudocoptisinechloride
- Purity
- 99.17%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0158969
- Product name
- Pseudocoptisinechloride
- Purity
- 99.17%
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0158969
- Product name
- Pseudocoptisinechloride
- Purity
- 99.17%
- Packaging
- 25mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- CS-0158969
- Product name
- Pseudocoptisinechloride
- Purity
- 99.17%
- Packaging
- 50mg
- Price
- $1450
- Updated
- 2021/12/16
- Product number
- CS-0158969
- Product name
- Pseudocoptisinechloride
- Purity
- 99.17%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
Pseudocoptisine chloride Chemical Properties,Usage,Production
Biological Activity
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
in vitro
Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.
in vivo
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, ip) are examined. Pseudocoptisine (2.0 mg/kg, po) significantly reverses cognitive impairments in mice by passive avoidance test.
Pseudocoptisine chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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