Tetrazine-NHS Ester
- Product Name
- Tetrazine-NHS Ester
- CAS No.
- 1616668-55-3
- Chemical Name
- Tetrazine-NHS Ester
- Synonyms
- Tetrazine-NHS Ester;Tetrazine-Ph-NHS ester;Tetrazine-NHS Ester (CCT-1127);3-(4-phenylacetic acid)-1,2,4,5-tetrazine succinimidyl ester;2,5-Dioxo-1-pyrrolidinyl 4-(1,2,4,5-tetrazin-3-yl)benzeneacetate;2,5-Dioxopyrrolidin-1-yl 2-(4-(1,2,4,5-tetrazin-3-yl)phenyl)acetate;Benzeneacetic acid, 4-(1,2,4,5-tetrazin-3-yl)-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB93345123
- Molecular Formula
- C14H11N5O4
- Formula Weight
- 313.27
- MOL File
- 1616668-55-3.mol
Tetrazine-NHS Ester Property
- Boiling point:
- 547.5±60.0 °C(Predicted)
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- DMSO : 100 mg/mL (319.21 mM; Need ultrasonic)
- pka
- 0.65±0.10(Predicted)
- form
- Solid
- color
- Pink to red
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 901989
- Product name
- Tetrazine-NHS ester
- Packaging
- 25MG
- Price
- $346
- Updated
- 2023/01/07
- Product number
- T4125
- Product name
- Tetrazine-NHS Ester
- Packaging
- 10MG
- Price
- $146
- Updated
- 2025/07/31
- Product number
- 35093
- Product name
- Tetrazine-NHS ester
- Purity
- ≥ 95% (HPLC)
- Packaging
- 25MG
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 35093
- Product name
- Tetrazine-NHS ester
- Purity
- ≥ 95% (HPLC)
- Packaging
- 100MG
- Price
- $295
- Updated
- 2021/12/16
- Product number
- 35093
- Product name
- Tetrazine-NHS ester
- Purity
- ≥ 95% (HPLC)
- Packaging
- 5MG
- Price
- $75
- Updated
- 2021/12/16
Tetrazine-NHS Ester Chemical Properties,Usage,Production
Description
Tetrazine-NHS Ester is a NHS activated tetrazine linker. NHS ester is very reactive with amine containing molecule. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene).
Uses
Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
IC 50
Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Tetrazine-NHS Ester Preparation Products And Raw materials
Raw materials
Preparation Products
Tetrazine-NHS Ester Suppliers
- Tel
- +1-5166625404;
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
- Country
- United States
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- +1-781-999-5354; +17819995354
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- United States
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- Tel
- +1-631-485-4226
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- 1-631-614-7828
- inquiry@bocsci.com
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- United States
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- 19552
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- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
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- 6618
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View Lastest Price from Tetrazine-NHS Ester manufacturers
- Product
- Tetrazine NHS ester 1616668-55-3
- Price
- US $0.00/mg
- Min. Order
- 25mg
- Purity
- >99.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-20