ChemicalBook > CAS DataBase List > LYN-1604

LYN-1604

Product Name: LYN-1604
CAS No.: 2088939-99-3
Chemical Name: LYN-1604
Synonyms: CS-2635;CS-2610;LYN-1604;LYN-1604 Hcl;LYN-1604 2HCl;LYN1604;LYN 1604;LYN-1604;LYN 1604;LYN1604;1-(4-(2-(2,4-Dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl)piperazin-1-yl)-2-(diisobutylamino)ethanone , LYN-1604;Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-
CBNumber: CB93353955
Molecular Formula: C33H43Cl2N3O2
Formula Weight: 584.62
MOL File: 2088939-99-3.mol

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LYN-1604 Property

Boiling point:: 670.9±55.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 8.03±0.50(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2921
Product name: LYN-1604 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $93.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2921
Product name: LYN-1604 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $301
Updated: 2025/07/31

Cayman Chemical

Product number: 24007
Product name: LYN-1604
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 24007
Product name: LYN-1604
Purity: ≥98%
Packaging: 5mg
Price: $317
Updated: 2024/03/01

Cayman Chemical

Product number: 24007
Product name: LYN-1604
Purity: ≥98%
Packaging: 10mg
Price: $593
Updated: 2024/03/01

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LYN-1604 Chemical Properties,Usage,Production

Description

LYN-1604 is an activator of unc-51-like kinase 1 (ULK1; EC₅₀ = 18.94 nM). It increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 triple-negative breast cancer (TNBC) cells in a concentration-dependent manner, indicating an increase in autophagy. It also increases the cleavage of the pro-apoptotic protein caspase-3. LYN-1604 decreases the viability of MDA-MB-231 cells in vitro (IC₅₀ = 1.66 μM), an effect that can be reversed by the autophagy inhibitor 3-methyladenine (3-MA; ). LYN-1604 (25, 50, and 100 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model.

Uses

LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC)[1].

in vivo

LYN-1604 (low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg; intragastric administration once a day for 14 days) inhibits the growth of xenograft TNBC by targeting ULK1-modulated cell death^[1].

Animal Model:	24 female nude mice (BALB/c, 6-8 weeks, 20-22 g)^[1]
Dosage:	Low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg
Administration:	Intragastric administration; once a day for 14 days
Result:	Significantly inhibited the growth of xenograft MDA-MB-231 cells. The body weights of mice were stable. By the end of the experiment, the liver and spleen weight indexes of mice were slightly increased in parts of the groups, while the kidney weight index was not affected in all dose groups.

IC 50

ULK1: 18.94 nM (EC₅₀)

References

[1] Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701. DOI:10.1039/c6sc05368h

LYN-1604 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LYN-1604 manufacturers

Career Henan Chemica Co

Product: LYN-1604 2088939-99-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

2088939-99-3, LYN-1604Related Search:

LYN-1604

LYN-1604 Hcl

CS-2610

CS-2635

LYN-1604;LYN 1604;LYN1604

LYN1604;LYN 1604

Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-

LYN-1604 2HCl

1-(4-(2-(2,4-Dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl)piperazin-1-yl)-2-(diisobutylamino)ethanone , LYN-1604

2088939-99-3

C33H43Cl2N3O2