ChemicalBook > CAS DataBase List > LYN-1604

LYN-1604

Product Name
LYN-1604
CAS No.
2088939-99-3
Chemical Name
LYN-1604
Synonyms
CS-2635;CS-2610;LYN-1604;LYN-1604 Hcl;LYN-1604 2HCl;LYN1604;LYN 1604;LYN-1604;LYN 1604;LYN1604;1-(4-(2-(2,4-Dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl)piperazin-1-yl)-2-(diisobutylamino)ethanone , LYN-1604;Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-
CBNumber
CB93353955
Molecular Formula
C33H43Cl2N3O2
Formula Weight
584.62
MOL File
2088939-99-3.mol
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LYN-1604 Property

Boiling point:
670.9±55.0 °C(Predicted)
Density 
1.168±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
8.03±0.50(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2921
Product name
LYN-1604 hydrochloride
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$93.5
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2921
Product name
LYN-1604 hydrochloride
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$301
Updated
2025/07/31
Cayman Chemical
Product number
24007
Product name
LYN-1604
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
24007
Product name
LYN-1604
Purity
≥98%
Packaging
5mg
Price
$317
Updated
2024/03/01
Cayman Chemical
Product number
24007
Product name
LYN-1604
Purity
≥98%
Packaging
10mg
Price
$593
Updated
2024/03/01
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LYN-1604 Chemical Properties,Usage,Production

Description

LYN-1604 is an activator of unc-51-like kinase 1 (ULK1; EC50 = 18.94 nM). It increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 triple-negative breast cancer (TNBC) cells in a concentration-dependent manner, indicating an increase in autophagy. It also increases the cleavage of the pro-apoptotic protein caspase-3. LYN-1604 decreases the viability of MDA-MB-231 cells in vitro (IC50 = 1.66 μM), an effect that can be reversed by the autophagy inhibitor 3-methyladenine (3-MA; ). LYN-1604 (25, 50, and 100 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model.

Uses

LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC)[1].

in vivo

LYN-1604 (low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg; intragastric administration once a day for 14 days) inhibits the growth of xenograft TNBC by targeting ULK1-modulated cell death[1].

Animal Model:24 female nude mice (BALB/c, 6-8 weeks, 20-22 g)[1]
Dosage:Low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg
Administration:Intragastric administration; once a day for 14 days
Result:Significantly inhibited the growth of xenograft MDA-MB-231 cells. The body weights of mice were stable. By the end of the experiment, the liver and spleen weight indexes of mice were slightly increased in parts of the groups, while the kidney weight index was not affected in all dose groups.

IC 50

ULK1: 18.94 nM (EC50)

References

[1] Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701. DOI:10.1039/c6sc05368h

LYN-1604 Preparation Products And Raw materials

Raw materials

Preparation Products

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LYN-1604 Suppliers

China 58 United States 6 Global 64
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29759
Advantage
68
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View Lastest Price from LYN-1604 manufacturers

Career Henan Chemica Co
Product
LYN-1604 2088939-99-3
Price
US $1.00/KG
Min. Order
1KG
Purity
MIn98%HPLC/LC
Supply Ability
100KGS
Release date
2020-10-29

2088939-99-3, LYN-1604Related Search:


  • LYN-1604
  • LYN-1604 Hcl
  • CS-2610
  • CS-2635
  • LYN-1604;LYN 1604;LYN1604
  • LYN1604;LYN 1604
  • Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-
  • LYN-1604 2HCl
  • 1-(4-(2-(2,4-Dichlorophenyl)-2-(naphthalen-2-ylmethoxy)ethyl)piperazin-1-yl)-2-(diisobutylamino)ethanone , LYN-1604
  • 2088939-99-3
  • C33H43Cl2N3O2