Gallamine triethiodide
- Product Name
- Gallamine triethiodide
- CAS No.
- 65-29-2
- Chemical Name
- Gallamine triethiodide
- Synonyms
- f2559;rp3697;relaxan;gallamin;flaxedil;flacedil;remyolan;retensin;tricuran;3.697r.p.
- CBNumber
- CB9336142
- Molecular Formula
- C30H60I3N3O3
- Formula Weight
- 891.53
- MOL File
- 65-29-2.mol
Gallamine triethiodide Property
- Melting point:
- 235 °C (dec.) (lit.)
- Density
- 1.4288 (estimate)
- storage temp.
- 2-8°C
- solubility
- H2O: 100 mg/mL
- form
- powder
- color
- Crystals from Me2CO (aq)
- Merck
- 13,4364
- InChIKey
- REEUVFCVXKWOFE-UHFFFAOYSA-K
- SMILES
- C1(OCC[N+](CC)(CC)CC)=C(C=CC=C1OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC.[I-].[I-].[I-]
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-45
- WGK Germany
- 3
- RTECS
- BS1100000
- HS Code
- 29239000
- Hazardous Substances Data
- 65-29-2(Hazardous Substances Data)
- Toxicity
- LD50 oral in rabbit: 100mg/kg
N-Bromosuccinimide Price
- Product number
- G8134
- Product name
- Gallamine triethiodide
- Purity
- ≥98% (TLC), powder, muscarinic receptor antagonist
- Packaging
- 5g
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 1288000
- Product name
- Gallamine triethiodide
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $390
- Updated
- 2022/05/15
- Product number
- 26086
- Product name
- Gallamine (iodide)
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 26086
- Product name
- Gallamine (iodide)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $77
- Updated
- 2024/03/01
- Product number
- G8134
- Product name
- Gallamine triethiodide
- Purity
- ≥98% (TLC), powder, muscarinic receptor antagonist
- Packaging
- 25g
- Price
- $657
- Updated
- 2024/03/01
Gallamine triethiodide Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Flaxedil,Davis and Geck,US,1951
Uses
Muscle relaxant;M2 antagonist allosteric
Uses
Gallamine triethiodide has been used:
- as a relaxant for measuring spinal trigeminal nucleus recordings from single neurons.
- as an antagonist in neuroblastoma cells as M2 receptor
- to reduce eye movement during retinal surgery in rat
Uses
Gallamine Triethiodide is used as a neuromuscular blocking agent, paralyzing locally during anesthetization.
Manufacturing Process
12.6 grams of pyrogallol are dissolved in 100 cc of hot toluene. 14 grams of
sodamide (85%)are added to the solution at about 100°C in 5 portions over a
period of 15 minutes, with agitation. There are then added with agitation,
over a period of 30 minutes, 100 cc of a toluene solution containing 474
grams of diethylaminochlorethane per liter of toluene.
The mixture is then heated for 1 hour, the toluene being refluxed, whereafter
it is left to cool, 50 cc of water are added and, after decanting, the solution is again washed with two quantities of 50 cc of water. The toluene solution is
dried over potassium carbonate and distilled in vacuo. There is thus obtained
28 grams of 1.2.3-tri-(β-diethylaminoethoxy)benzene, boiling at 206°C under
1 mm pressure.
20 grams of 1.2.3-tri-(β-diethylaminoethoxy)-benzene is heated for 5 hours
under reflux on the water bath with 30 grams of ethyl iodide. The hot mixture
is dissolved in 50 cc of water, filtered after addition of 2 grams of decolorizing
black, evaporated to dryness on the water bath and recrystallized from 120 cc
of alcohol. The product can be further recrystallized in mixtures of acetone
and water.
The triethiodide of 1.2.3-tri-(β-diethylaminoethoxy)-benzene is thus obtained
as white crystals which, after drying, have a rather indefinite melting point at
about 152° to 153°C, (Maquenne block).
Therapeutic Function
Muscle relaxant
General Description
Gallamine triethiodide,[v-phenenyl-tris(oxyethylene)]tris[triethylammonium] triiodide(Flaxedil), is a skeletal muscle relaxant that works byblocking neuromuscular transmission in a manner similar tothat of d-tubocurarine (i.e., a nondepolarizing blockingagent). It does have some differences, however. It has astrong vagolytic effect and a persistent decrease in neuromuscularfunction after successive doses that cannot be overcome by cholinesterase inhibitors. Gallamine triethiodidealso has muscarinic antagonistic properties and bindswith greater affinity to the M2 receptors than to the M1 receptor.This latter characteristic may cause its strongvagolytic action.
Biochem/physiol Actions
Gallamine triethiodide has anti-muscarinic effect. It is a competitive antagonist for the muscarinic receptor. Gallamine is regarded as neuromuscular blocking agent.
Clinical Use
Gallamine Triethiodide is contraindicated in patients with myastheniagravis, and one should remember that its action is cumulative,as with curare. The antidote for gallamine triethiodideis neostigmine.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, parenteral, intraduodenal, intraperitoneal, and intramuscular routes. Whenheated to decomposition it emits very toxic fumes of NH3, NOx, and Ií.
Synthesis
Gallamine, 1,2,3-tris-(2-triethylaminoethoxy)benzene triiodide, is synthesized from pyrogallol, the hydroxyl groups of which are esterified by 2-diethylaminoethylchloride in the presence of sodium amide. The resulting 1,2,3-tris-(2-triethylaminoethoxy) benzene is further alkylated at all three nitrogen atoms by ethyliodide, giving gallamine.
Gallamine triethiodide Preparation Products And Raw materials
Raw materials
Preparation Products
Gallamine triethiodide Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9823
- Advantage
- 79
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19918
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- SALES@UHNSHANGHAI.COM
- Country
- China
- ProdList
- 977
- Advantage
- 58
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- +86-21-65211385-8001 36031160
- Fax
- +86-21-65211385-8004
- sales@shruji.com
- Country
- China
- ProdList
- 3224
- Advantage
- 55
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9986
- Advantage
- 55
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 4000-819-385 010-62329685 13718666987
- Fax
- 010-62340519
- Country
- China
- ProdList
- 1971
- Advantage
- 55
- Tel
- 028-88469284 18000562381
- rzbtsj@163.com
- Country
- China
- ProdList
- 9958
- Advantage
- 56
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3868
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20810
- Advantage
- 60
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 13672434928
- Fax
- -
- 3307355104@qq.com
- Country
- China
- ProdList
- 3650
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 15503
- Advantage
- 58
- Tel
- 021-58958002 18930822973
- Fax
- 021-58958618
- xiaoyangw@gmail.com
- Country
- China
- ProdList
- 2129
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 13739298932
- 531626407@qq.com
- Country
- China
- ProdList
- 2999
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- +8613288715578
- sales@hbmojin.com
- Country
- China
- ProdList
- 12456
- Advantage
- 58
- Tel
- +8617531190177
- peter@yan-xi.com
- Country
- China
- ProdList
- 5993
- Advantage
- 58
- Tel
- 0551-65418671
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34572
- Advantage
- 58
- Tel
- 571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- CHINA
- ProdList
- 52867
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 29016
- Advantage
- 58
- Tel
- 0371-63284658; 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 15901914505
- Fax
- 021-54389085
- 3187892335@qq.com
- Country
- China
- ProdList
- 9102
- Advantage
- 58
- Tel
- +86-023-61398051 +8613650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39916
- Advantage
- 58
- Tel
- 021-61998208 18217752821
- Fax
- 021-37680378
- sales@klbio.cn
- Country
- China
- ProdList
- 9617
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49390
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4196
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 13675144456
- Fax
- 025-85563444
- sean.lv@synzest.com
- Country
- China
- ProdList
- 10787
- Advantage
- 58
- Tel
- 18642120371
- 2837458851@qq.com
- Country
- China
- ProdList
- 9925
- Advantage
- 58
- Tel
- 0512-87182056 13451648594
- Fax
- 0512-87182056
- sales@yacoo.com.cn
- Country
- China
- ProdList
- 5000
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 9946
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44490
- Advantage
- 58
View Lastest Price from Gallamine triethiodide manufacturers
- Product
- Gallamine triethiodide 65-29-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000
- Release date
- 2024-03-25
- Product
- Gallamine triethiodide 65-29-2
- Price
- US $10.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-07
- Product
- Gallamine triethiodide 65-29-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-11-30