ChemicalBook > CAS DataBase List > PC Alkyne-PEG4-NHS carbonate ester
PC Alkyne-PEG4-NHS carbonate ester
- Product Name
- PC Alkyne-PEG4-NHS carbonate ester
- CAS No.
- 1802907-98-7
- Chemical Name
- PC Alkyne-PEG4-NHS carbonate ester
- Synonyms
- PC Alkyne-PEG4-NHS ester;PC Alkyne-PEG4-NHS carbonate ester;2,5-Dioxopyrrolidin-1-yl (1-(5-methoxy-2-nitro-4-((17-oxo-4,7,10,13-tetraoxa-16-azaicos-1-yn-20-yl)oxy)phenyl)ethyl) carbonate;Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-azaeicos-19-yn-1-yl)oxy]phenyl]ethyl ester
- CBNumber
- CB93363978
- Molecular Formula
- C29H39N3O14
- Formula Weight
- 653.63
- MOL File
- 1802907-98-7.mol
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PC Alkyne-PEG4-NHS carbonate ester Property
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Storage temp. -20°C
- form
- Viscous Liquid
- pka
- 15.38±0.46(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
BroadPharm
- Product number
- BP-22956
- Product name
- PCAlkyne-PEG4-NHScarbonateester
- Purity
- 95%
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
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PC Alkyne-PEG4-NHS carbonate ester Chemical Properties,Usage,Production
Description
PC Alkyne-PEG4-NHS carbonate ester is a photocleavable linker with an alkyne and NHS carbonate ester end group. The NHS ester can react with primary amines. The alkyne can participate in copper-catalyzed Click Chemistry reactions with azide moieties.
Uses
PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
PC Alkyne-PEG4-NHS carbonate ester Preparation Products And Raw materials
Raw materials
Preparation Products
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PC Alkyne-PEG4-NHS carbonate ester Suppliers
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- 400-164-7117 13681763483
- Fax
- +86-21-61629029
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- China
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- et@chemextension.com
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View Lastest Price from PC Alkyne-PEG4-NHS carbonate ester manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- PC Alkyne-PEG4-NHS ester 1802907-98-7
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >99.00%
- Supply Ability
- 50mg
- Release date
- 2024-03-21