MD2-IN-1
- Product Name
- MD2-IN-1
- CAS No.
- 111797-22-9
- Chemical Name
- MD2-IN-1
- Synonyms
- MDK7229;MDK 7229;MD2-IN-1;MD2 inhibitor 1;MD2-IN-1; MDK7229; MDK 7229; MDK 7229;1-(3,4-Dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-;inhibit,Inhibitor,MD2IN1,Toll-like Receptor (TLR),MD-2-IN-1,MD2 IN 1
- CBNumber
- CB93373067
- Molecular Formula
- C20H22O6
- Formula Weight
- 358.39
- MOL File
- 111797-22-9.mol
MD2-IN-1 Property
- Melting point:
- 131-132 °C
- Boiling point:
- 521.3±50.0 °C(Predicted)
- Density
- 1.156±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (139.51 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-7984
- Product name
- MD2-IN-1
- Purity
- 99.85%
- Packaging
- 1mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- CS-7984
- Product name
- MD2-IN-1
- Purity
- 99.85%
- Packaging
- 5mg
- Price
- $396
- Updated
- 2021/12/16
- Product number
- CS-7984
- Product name
- MD2-IN-1
- Purity
- 99.85%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CS-7984
- Product name
- MD2-IN-1
- Purity
- 99.85%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- CS-7984
- Product name
- MD2-IN-1
- Purity
- 99.85%
- Packaging
- 100mg
- Price
- $2520
- Updated
- 2021/12/16
MD2-IN-1 Chemical Properties,Usage,Production
Biological Activity
MD2-IN-1 is an inhibitor of myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.
in vitro
Myeloid differentiation protein 2 (MD2) is a co-receptor of TLR4. Among those derivatives, MD2-IN-1 (compound 20) shows the strongest inhibitory effect on LPS-induced expression of both TNF-α and IL-6. Compare to the vehicle, LPS alone largely increases the amount of TLR4/MD2 complex, while pretreatment with MD2-IN-1 inhibits the increase of TLR4/MD2 complex to the vehicle level. SPR analysis shows that MD2-IN- 1 exhibits recognizable binding to rhMD2 protein in a dose-dependent manner, with a KD value of 189 μM, while the KD value of xanthohumol binding to MD2 is 460 μM. Pre-treatment with different doses of MD2-IN-1 dose-dependently FITC-LPS binding to MD2 in cell surface membranes reduces FITC-LPS binding to MD2 in cell surface membranes, with a 65% inhibition at 10 μM in terms of mean fluorescence intensity. Pretreatment with MD2-IN-1 also dose-dependently blocks LPS-induced MAPK phosphorylation in the MPMs.
in vivo
Administration of MD2-IN-1 evidently reduces the LPS-induced increase in protein concentrations in BALF. The lung wet/dry weight ratio is markedly higher in the LPS-treated group than the control group, and MD2- IN-1 treatment reduces LPS-induced pulmonary edema. LPS also causes observable lung histopathologic changes, including areas of inflammatory infiltration, hemorrhage, interstitial edema, thickening of the alveolar wall, and lung tissue destruction. These histopathological changes are ameliorated in the MD2- IN-1 treatment group.
target
| Target | Value |
| MD2 () | 189 μM(Kd) |
MD2-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
MD2-IN-1 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
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- 708-557-7486
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- United States
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- +1-+1(833)-552-7181
- sales@aladdinsci.com
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- United States
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- support@targetmol.com
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- United States
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- sales@medchemexpress.com
- Country
- United States
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View Lastest Price from MD2-IN-1 manufacturers
- Product
- MD2-IN-1 111797-22-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23