m-PEG5-succinimidyl carbonate

Product Name: m-PEG5-succinimidyl carbonate
CAS No.: 1058691-00-1
Chemical Name: m-PEG5-succinimidyl carbonate
Synonyms: m-PEG5-succinimidyl carbonate;14-methoxy-3,6,9,12-tetraoxa tetradecanyl N-succinimidyl carbonate;2,5,8,11,14,17-Hexaoxaoctadecanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB93373663
Molecular Formula: C16H27NO10
Formula Weight: 393.39
MOL File: 1058691-00-1.mol

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m-PEG5-succinimidyl carbonate Property

Boiling point:: 469.3±55.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23729
Product name: m-PEG5-succinimidylcarbonate
Purity: 98%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

BroadPharm

Product number: BP-23729
Product name: m-PEG5-succinimidylcarbonate
Purity: 98%
Packaging: 250mg
Price: $480
Updated: 2021/12/16

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m-PEG5-succinimidyl carbonate Chemical Properties,Usage,Production

Description

m-PEG5-succinimidyl carbonate is a PEG linker with an attached succinumidyl carbonate group. The succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles.

Uses

m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

IC 50

PEGs; Alkyl/ether; Non-cleavable Linker

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

m-PEG5-succinimidyl carbonate Preparation Products And Raw materials

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m-PEG5-succinimidyl carbonate Suppliers

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1058691-00-1, m-PEG5-succinimidyl carbonateRelated Search:

m-PEG5-succinimidyl carbonate

2,5,8,11,14,17-Hexaoxaoctadecanoic acid, 2,5-dioxo-1-pyrrolidinyl ester

14-methoxy-3,6,9,12-tetraoxa tetradecanyl N-succinimidyl carbonate

1058691-00-1