N-(Azido-PEG3)-N-Fluorescein-PEG4-acid
- Product Name
- N-(Azido-PEG3)-N-Fluorescein-PEG4-acid
- CAS No.
- 2100306-72-5
- Chemical Name
- N-(Azido-PEG3)-N-Fluorescein-PEG4-acid
- Synonyms
- N-(Azido-PEG3)-N-Fluorescein-PEG4-acid
- CBNumber
- CB93373698
- Molecular Formula
- C40H49N5O14S
- Formula Weight
- 855.91
- MOL File
- 2100306-72-5.mol
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Chemical Properties,Usage,Production
Uses
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
N-(Azido-PEG3)-N-Fluorescein-PEG4-acid Suppliers
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
- Country
- China
- ProdList
- 4952
- Advantage
- 58
- Tel
- 0755-23251735 13302967066
- sales@geneseqtools.com
- Country
- China
- ProdList
- 1420
- Advantage
- 58
- Tel
- 13303867194
- 3001317055@qq.com
- Country
- China
- ProdList
- 9681
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 0431-80514535 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 5061
- Advantage
- 58
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 29423
- Advantage
- 58
- Tel
- 176345344 7 17634854698
- 1959525201@qq.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- +86-15680926068
- 1924344760@confluore.cn
- Country
- China
- ProdList
- 2997
- Advantage
- 58
- Tel
- +undefined18143011203
- info@chemextension.com
- Country
- China
- ProdList
- 42056
- Advantage
- 58
View Lastest Price from N-(Azido-PEG3)-N-Fluorescein-PEG4-acid manufacturers
- Product
- N-(Azido-PEG3)-N-Fluorescein-PEG4-acid 2100306-72-5
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- >95.00%
- Supply Ability
- 5mg
- Release date
- 2024-03-28