NH-bis(PEG2-propargyl)
- Product Name
- NH-bis(PEG2-propargyl)
- CAS No.
- 2100306-83-8
- Chemical Name
- NH-bis(PEG2-propargyl)
- Synonyms
- NH-(PEG2-propargyl)2;NH-bis(PEG2-propargyl);2-(2-prop-2-ynoxyethoxy)-N-[2-(2-prop-2-ynoxyethoxy)ethyl]ethanamine;Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]-N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-
- CBNumber
- CB93373739
- Molecular Formula
- C14H23NO4
- Formula Weight
- 269.34
- MOL File
- 2100306-83-8.mol
NH-bis(PEG2-propargyl) Property
- Boiling point:
- 351.0±37.0 °C(Predicted)
- Density
- 1.030±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- solubility
- Soluble in Water, DMSO, DCM, DMF
- pka
- 8.36±0.19(Predicted)
- form
- Viscous Liquid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- BP-23613
- Product name
- NH-bis(PEG2-propargyl)
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-23613
- Product name
- NH-bis(PEG2-propargyl)
- Purity
- 98%
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- BP-23613
- Product name
- NH-bis(PEG2-propargyl)
- Purity
- 98%
- Packaging
- 500mg
- Price
- $980
- Updated
- 2021/12/16
NH-bis(PEG2-propargyl) Chemical Properties,Usage,Production
Description
NH-bis(PEG2-propargyl) is a multi-branched linker with two terminal propargyl groups and an amino group. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. The amino group is reactive with carboxylic acids, activated NHS esters, and carbonyls.
Uses
NH-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
NH-bis(PEG2-propargyl) Preparation Products And Raw materials
Raw materials
Preparation Products
NH-bis(PEG2-propargyl) Suppliers
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- 400-164-7117 13681763483
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View Lastest Price from NH-bis(PEG2-propargyl) manufacturers
- Product
- NH-bis(PEG2-propargyl) 2100306-83-8
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-28