9,11-DIOXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID Property

Boiling point:

551.8±50.0 °C(Predicted)

Density 

1.127±0.06 g/cm3(Predicted)

solubility 

DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12,

pka

4.77±0.10(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

9,11-DIOXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID Chemical Properties,Usage,Production

Description

Prostaglandin K₁ (PGK₁) is a 9,11-diketo analog of PGE₁ or PGD₁ . It is a PGE₂ receptor subtype EP₁ agonist that has 387-fold reduced potency compared to PGE₂ .¹

Definition

ChEBI: PGK1 is a prostanoid.

References

1. Ungrin, M.D., Carrière, M.C., Denis, D., et al. Key structural features of prostaglandin E₂ and prostanoid analogs involved in binding and activation of the human EP₁ prostanoid receptor Mol. Pharmacol. 59(6),1446-1456(2001).