ChemicalBook > CAS DataBase List > sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

Product Name
sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
CAS No.
2070009-41-3
Chemical Name
sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
Synonyms
Antipyrine Impurity 15;Rosuvastatin Sodium Salt-D6;(3R,5S,E)-7-(4-(4-fluorophenyl)-2-(N-methylmethylsulfonamido)-6-(propan-2-yl-1,1,1,3,3,3-d6)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate,monosodiumsalt;sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate;Rosuvastatin Sodium D6Q: What is Rosuvastatin Sodium D6 Q: What is the CAS Number of Rosuvastatin Sodium D6 Q: What is the storage condition of Rosuvastatin Sodium D6 Q: What are the applications of Rosuvastatin Sodium D6
CBNumber
CB93400796
Molecular Formula
C22H29FN3NaO6S
Formula Weight
505.54
MOL File
2070009-41-3.mol
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sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate Property

storage temp. 
Store at 4°C
solubility 
Methanol: Soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23359
Product name
Rosuvastatin-d6 (sodium salt)
Purity
≥98%
Packaging
500μg
Price
$231
Updated
2024/03/01
Cayman Chemical
Product number
23359
Product name
Rosuvastatin-d6 (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$414
Updated
2024/03/01
Cayman Chemical
Product number
23359
Product name
Rosuvastatin-d6 (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$1468
Updated
2024/03/01
AK Scientific
Product number
5853DV
Product name
Rosuvastatin(D6Sodium)
Packaging
1mg
Price
$559
Updated
2021/12/16
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sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate Chemical Properties,Usage,Production

Biological Activity

Rosuvastatin-d6 is intended for use as an internal standard for the quantification of rosuvastatin by GC- or LC-MS. Rosuvastatin is an HMG-CoA reductase inhibitor (IC50 = 5 nM).1,2 It is a fully-synthetic inhibitor that is designed to maximize the points of contact with, and inhibition of, HMG-CoA reductase.1 Formulations containing rosuvastatin reduce low-density lipoprotein and C-reactive protein and increase high-density lipoprotein in humans.3,4

References

1.Istvan, E.S., and Deisenhofer, J.Structural mechanism for statin inhibition of HMG-CoA reductaseScience292(5519)1160-1164(2001) 2.Tobert, J.A.Lovastatin and beyond: The history of the HMG-CoA reductase inhibitorsNat. Rev. Drug Discov.2(7)517-526(2003) 3.Asztalos, B.F., Maulf, F.L., Dallal, G.E., et al.Comparison of the effects of high doses of Rosuvastatin versus Atorvastatin on the subpopulations of high-density lipoproteinsAm. J. Cardiol.99(5)681-685(2007) 4.Rubba, P., Marotta, G., and Gentile, M.Efficacy and safety of rosuvastatin in the management of dyslipidemiaVasc. Health Risk Manag.5(1)343-352(2009)

sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate Preparation Products And Raw materials

Raw materials

Preparation Products

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sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate Suppliers

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2070009-41-3, sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoateRelated Search:

3-Oxo Rosuvastatin SodiuM Salt N-Desmethyl Rosuvastatin Lactone tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate (4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester Rosuvastatin ethyl ester Rosuvastatin Impurity 91 Rosuvastatin Related Compound 8 Rosuvastatin Calcium Salt tert-Butyl 2-((4S,6S)-6-(chloromethyl(02,2-1,3-dioxan-4-yl)acetate NGABCYSYENPREI-RYUDHWBXSA-N 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylic acid Rosuvastatin EP Impurity C Rosuvastatin EP impurity H Desfluoro Rosuvastatin Sodium Salt 5-PyriMidinecarboxylic acid, 4-(4-fluorophenyl)-1,2-dihydro-6-(1-Methylethyl)-2-oxo-, Methyl ester Phosphonium, [[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]me Ethyl propionylacetate Rosuvastatin Impurity 4

  • sodium:(E,3R,5S)-7-[4-(4-fluorophenyl)-6-(1,1,1,3,3,3-hexadeuteriopropan-2-yl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
  • (3R,5S,E)-7-(4-(4-fluorophenyl)-2-(N-methylmethylsulfonamido)-6-(propan-2-yl-1,1,1,3,3,3-d6)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate,monosodiumsalt
  • Rosuvastatin Sodium D6Q: What is Rosuvastatin Sodium D6 Q: What is the CAS Number of Rosuvastatin Sodium D6 Q: What is the storage condition of Rosuvastatin Sodium D6 Q: What are the applications of Rosuvastatin Sodium D6
  • Rosuvastatin Sodium Salt-D6
  • Antipyrine Impurity 15
  • 2070009-41-3