ChemicalBook > CAS DataBase List > 2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID
2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID
- Product Name
- 2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID
- CAS No.
- 287118-97-2
- Chemical Name
- 2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID
- Synonyms
- NCX 4040;NO-Aspirin;NO-ASPIRIN 2;2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester;2-(Acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester;2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID;Benzoic acid, 2-(acetyloxy)-, 4-[(nitrooxy)methyl]phenyl ester
- CBNumber
- CB9343492
- Molecular Formula
- C16H13NO7
- Formula Weight
- 331.28
- MOL File
- 287118-97-2.mol
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2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID Property
- Melting point:
- 83-86°C
- Boiling point:
- 495.7±40.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble15mg/mL (clear solution)
- form
- powder
- color
- white to beige
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 41-43
- Safety Statements
- 26-36/37-39
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H318Causes serious eye damage
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0414
- Product name
- NCX 4040
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0414
- Product name
- NCX 4040
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $353
- Updated
- 2024/03/01
Tocris
- Product number
- 4531
- Product name
- NCX 4040
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
Tocris
- Product number
- 4531
- Product name
- NCX 4040
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $666
- Updated
- 2021/12/16
TRC
- Product number
- N633005
- Product name
- NO-Aspirin
- Packaging
- 250mg
- Price
- $1060
- Updated
- 2021/12/16
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2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
A novel nitric oxide-releasing aspirin,
Biochem/physiol Actions
NCX 4040 is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumor cell lines.
2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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