5-FORMYL-2-THIOPHENECARBOXYLIC ACID

Product Name: 5-FORMYL-2-THIOPHENECARBOXYLIC ACID
CAS No.: 4565-31-5
Chemical Name: 5-FORMYL-2-THIOPHENECARBOXYLIC ACID
Synonyms: AKOS MSC-0225;AURORA KA-6755;5-FORMYLTHENOIC ACID;5-formyl-2-thiophenecarboxylate;2-Formyl-5-thiophenecarboxylic acid;5-FORMYL-2-THIOPHENECARBOXYLIC ACID;5-FORMYL-THIOPHEN-2-CARBOXYLIC ACID;5-Carboxy-2-thiophenecarboxaldehyde;5-FORMYL-THIOPHENE-2-CARBOXYLIC ACID;5-Formyl-2-thiophenecarboxylicAcid>
CBNumber: CB9349393
Molecular Formula: C6H4O3S
Formula Weight: 156.16
MOL File: 4565-31-5.mol

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5-FORMYL-2-THIOPHENECARBOXYLIC ACID Property

Melting point:: 169 °C
Boiling point:: 371.4±27.0 °C(Predicted)
Density: 1.514±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 3.05±0.10(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C6H4O3S/c7-3-4-1-2-5(10-4)6(8)9/h1-3H,(H,8,9)
InChIKey: VFEAMMGYJFFXKV-UHFFFAOYSA-N
SMILES: C1(C(O)=O)SC(C=O)=CC=1
CAS DataBase Reference: 4565-31-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-36
Hazard Note: Irritant
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0336
Product name: 5-Formyl-2-thiophenecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $85
Updated: 2025/07/31

TCI Chemical

Product number: F0336
Product name: 5-Formyl-2-thiophenecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $215
Updated: 2025/07/31

TRC

Product number: F701050
Product name: 5-FormylthenoicAcid
Packaging: 25mg
Price: $125
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6H21-1-X0
Product name: 5-Formylthiophene-2-carboxylic acid
Packaging: 1g
Price: $93
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK424250
Product name: 5-Formyl-2-thiophenecarboxylic Acid
Purity: 98%
Packaging: 1g
Price: $129
Updated: 2021/12/16

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5-FORMYL-2-THIOPHENECARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Bright red solid

Uses

5-Formyl-2-thiophenecarboxylic acid is a thiophene derivative as immunomodulating agents useful in the treatment of autoimmune diseases.

Synthesis

67808-64-4

4565-31-5

General procedure for the synthesis of 5-formyl-2-thiophenecarboxylic acid from methyl 5-formylthiophene-2-carboxylate: the compound methyl 5-formylthiophene-2-carboxylic acid (2 g, 12.8 mmol) was dissolved in 200 mL of a mixed solvent (THF:H2O = 1:1), and the hydrolysis reaction was carried out by adding KOH (1.1 g, 19.2 mmol). Upon completion of the reaction, THF was removed by distillation under reduced pressure.Subsequently, the pH of the aqueous layer was adjusted to 1-2 with 1N HCl solution and extracted with ethyl acetate (200 mL × 5), resulting in the target compound 5-formyl-2-thiophenecarboxylic acid (1.2 g, 59% yield).1H NMR (300 MHz, CDCl3) δ 10.00 (s, 1H), 7.93- 7.92 (d, J = 3.92 Hz, 1H), 7.78-7.77 (d, J = 3.9 Hz, 1H).13C NMR (300 MHz, CDCl3) δ 182.2, 163.30, 141.57, 139.70, 133.79, 132.

References

[1] Patent: WO2004/37808, 2004, A1. Location in patent: Page 14-15; 93

5-FORMYL-2-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

2-Thiophenecarboxaldehyde Benzene N,N-Dimethylethylenediamine 1,2-Dimethoxyethane n-Butyllithium

Preparation Products

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5-FORMYL-2-THIOPHENECARBOXYLIC ACID Suppliers

Americas 1 Austria 1 Canada 1 China 115 Europe 1 Germany 5 India 4 Japan 2 Russia 1 The Netherlands 1 United Kingdom 7 United States 16 Global 155

Specs

Tel: --
Fax: --
Email: info@specs.net
Country: The Netherlands
ProdList: 6833
Advantage: 70

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View Lastest Price from 5-FORMYL-2-THIOPHENECARBOXYLIC ACID manufacturers

Hinova Pharma

Product: 5-FORMYL-2-THIOPHENECARBOXYLIC ACID 4565-31-5
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.0
Supply Ability: 1000kg
Release date: 2025-07-01

Career Henan Chemical Co

Product: 5-FORMYL-2-THIOPHENECARBOXYLIC ACID 4565-31-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

4565-31-5, 5-FORMYL-2-THIOPHENECARBOXYLIC ACIDRelated Search:

5-Formyl-2-thiophenecarboxylic acid methyl ester 2,5-Thiophenedicarboxylic acid 3,4-Dihydroxy-thiophene-2,5-dicarboxylic acid dimethyl ester 5-FORMYL-2-THIOPHENECARBOXYLIC ACID 5-Acetylthiophene-2-carboxylic acid 2,5-Dicarboxylic acid-3,4-ethylenedioxythiophene Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-, diethyl ester 2-CHLORO-5-(5-ETHOXYCARBONYL-2-THENOYL)PYRIDINE 2-CHLORO-3-(5-ETHOXYCARBONYL-2-THENOYL)PYRIDINE 2,5-Thiophenedicarboxylic acid dimethyl ester THIOPHENE-2,5-DICARBOXYLIC ACID DISODIUM SALT ETHYL 5-THENOYL-2-THIOPHENE CARBOXYLATE 2-Formyl-3-thiophenecarboxylic acid methyl ester 3-Formyl-2-thiophenecarboxylic acid methyl ester 2-Formyl-3-thiophenecarboxylic acid 5-Formyl-3-thiophenecarboxylic acid 4-Formyl-2-thiophenecarboxylic acid 3-formyl-2-thiophenecarboxylic acid

AKOS MSC-0225

5-FORMYLTHENOIC ACID

5-FORMYL-THIOPHENE-2-CARBOXYLIC ACID

5-FORMYL-THIOPHEN-2-CARBOXYLIC ACID

5-FORMYL-2-THIOPHENECARBOXYLIC ACID

AURORA KA-6755

5-Formyl-2-thiophenecarboxylic acid ,98%

5-Carboxythiophene-2-carboxaldehyde, 2-Carboxy-5-formylthiophene, 5-Formyl-2-thenoic acid

5-ForMyl-thiophene-2-carboxylic acid aMide

5-formyl-2-thiophenecarboxylate

2-Formyl-5-thiophenecarboxylic acid

5-Formyl-2-thiophenecarboxylicAcid&gt

2-Thiophenecarboxylic acid, 5-formyl-

5-Carboxy-2-thiophenecarboxaldehyde

2-methyl-1,3-thiazole-25-carboxylic acid

4565-31-5

4535-31-5

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds