FWMUIOJZHOPPDX-UHFFFAOYSA-N

Product Name: FWMUIOJZHOPPDX-UHFFFAOYSA-N
CAS No.: 1638526-21-2
Chemical Name: FWMUIOJZHOPPDX-UHFFFAOYSA-N
Synonyms: EMT inhibitor-1;FWMUIOJZHOPPDX-UHFFFAOYSA-N;EMT inhibitor1,EMT inhibitor 1;EMT inhibitor-1, 10 mM in DMSO;4-((4-(3,4-Dichlorophenyl)-1,2,5-thiadiazol-3-yl)oxy)butan-1-ol;1-Butanol, 4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]-
CBNumber: CB93509723
Molecular Formula: C12H12Cl2N2O2S
Formula Weight: 319.21
MOL File: 1638526-21-2.mol

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FWMUIOJZHOPPDX-UHFFFAOYSA-N Property

Boiling point:: 443.3±45.0 °C(Predicted)
Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 5.6 mg/mL (17.54 mM)
form: Solid
pka: 14.96±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0021073
Product name: EMTinhibitor-1
Purity: 98.71%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0021073
Product name: EMTinhibitor-1
Purity: 98.71%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0021073
Product name: EMTinhibitor-1
Purity: 98.71%
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC12273
Product name: EMTinhibitor-1
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC12273
Product name: EMTinhibitor-1
Purity: >98%
Packaging: 1g
Price: $3800
Updated: 2021/12/16

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FWMUIOJZHOPPDX-UHFFFAOYSA-N Chemical Properties,Usage,Production

Uses

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

in vivo

EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex^[1].C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).

References

[1] Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67. DOI:10.1158/1535-7163.MCT-13-0918

FWMUIOJZHOPPDX-UHFFFAOYSA-N Preparation Products And Raw materials

Raw materials

Preparation Products

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FWMUIOJZHOPPDX-UHFFFAOYSA-N Suppliers

China 28 United States 3 Global 31

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1638526-21-2, FWMUIOJZHOPPDX-UHFFFAOYSA-NRelated Search:

FWMUIOJZHOPPDX-UHFFFAOYSA-N

EMT inhibitor-1

1-Butanol, 4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]-

EMT inhibitor1,EMT inhibitor 1

4-((4-(3,4-Dichlorophenyl)-1,2,5-thiadiazol-3-yl)oxy)butan-1-ol

EMT inhibitor-1, 10 mM in DMSO

1638526-21-2