FWMUIOJZHOPPDX-UHFFFAOYSA-N
- Product Name
- FWMUIOJZHOPPDX-UHFFFAOYSA-N
- CAS No.
- 1638526-21-2
- Chemical Name
- FWMUIOJZHOPPDX-UHFFFAOYSA-N
- Synonyms
- EMT inhibitor-1;FWMUIOJZHOPPDX-UHFFFAOYSA-N;EMT inhibitor1,EMT inhibitor 1;EMT inhibitor-1, 10 mM in DMSO;4-((4-(3,4-Dichlorophenyl)-1,2,5-thiadiazol-3-yl)oxy)butan-1-ol;1-Butanol, 4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]-
- CBNumber
- CB93509723
- Molecular Formula
- C12H12Cl2N2O2S
- Formula Weight
- 319.21
- MOL File
- 1638526-21-2.mol
FWMUIOJZHOPPDX-UHFFFAOYSA-N Property
- Boiling point:
- 443.3±45.0 °C(Predicted)
- Density
- 1.415±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 5.6 mg/mL (17.54 mM)
- form
- Solid
- pka
- 14.96±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0021073
- Product name
- EMTinhibitor-1
- Purity
- 98.71%
- Packaging
- 5mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CS-0021073
- Product name
- EMTinhibitor-1
- Purity
- 98.71%
- Packaging
- 10mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CS-0021073
- Product name
- EMTinhibitor-1
- Purity
- 98.71%
- Packaging
- 25mg
- Price
- $1500
- Updated
- 2021/12/16
- Product number
- DC12273
- Product name
- EMTinhibitor-1
- Purity
- >98%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- DC12273
- Product name
- EMTinhibitor-1
- Purity
- >98%
- Packaging
- 1g
- Price
- $3800
- Updated
- 2021/12/16
FWMUIOJZHOPPDX-UHFFFAOYSA-N Chemical Properties,Usage,Production
Uses
EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
in vivo
EMT inhibitor-1 (C19) (intraperitoneal injection; 5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1].C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).
References
[1] Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67. DOI:10.1158/1535-7163.MCT-13-0918
FWMUIOJZHOPPDX-UHFFFAOYSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
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