Diphenylpyraline Hydrochloride
- Product Name
- Diphenylpyraline Hydrochloride
- CAS No.
- 132-18-3
- Chemical Name
- Diphenylpyraline Hydrochloride
- Synonyms
- Lergobine;Hy-stamin;DIPHENYLPYRALINE HCL;LABOTEST-BB LT00159897;Diphenylpyraline hydrochlorid;DIPHENYLPYRALINE HYDROCHLORIDE;4-(benzhydryloxy)-1-methylpiperidine;4-diphenylmethoxy-1-methylpiperidine;4-(Diphenyl Methoxy)-1-piperidine HCl;4-BENZHYDRYLOXY-1-METHYL PIPERIDINE HCL
- CBNumber
- CB9356441
- Molecular Formula
- C19H24ClNO
- Formula Weight
- 317.85
- MOL File
- 132-18-3.mol
Diphenylpyraline Hydrochloride Property
- Melting point:
- 203-205 °C(lit.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Merck
- 13,3363
- Stability:
- Hygroscopic
- EPA Substance Registry System
- Diphenylpyraline hydrochloride (132-18-3)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 26-36
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- TM7823600
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- mouse,LD50,intramuscular,64300ug/kg (64.3mg/kg),Drugs in Japan Vol. 6, Pg. 333, 1982.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 280550
- Product name
- 4-Diphenylmethoxy-1-methylpiperidine hydrochloride
- Purity
- 95%
- Packaging
- 10g
- Price
- $41.6
- Updated
- 2024/03/01
- Product number
- D492113
- Product name
- DiphenylpyralineHydrochloride
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D492113
- Product name
- DiphenylpyralineHydrochloride
- Packaging
- 2.5g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- A8415
- Product name
- DiphenylpyralineHCl
- Packaging
- 10mM(in 1mL H2O)
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-4455
- Product name
- Diphenylpyraline(hydrochloride)
- Purity
- 99.25%
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
Diphenylpyraline Hydrochloride Chemical Properties,Usage,Production
Description
Diphenylpyraline is an antihistamine drug with anticholinergic and sedative action. It is intended for symptomatic treatment of seasonal allergies and allergic reactions as well as an adjuvant drug in anaphylactic reaction therapy. Synonyms of this drug are arbid, timpil, histryl, hispril, and others.
Originator
Diafen,Riker,US,1955
Uses
Antihistaminic;H1 antagonist
Uses
Diphenylpyraline Hydrochloride is a salt of Diphenylpyraline (D492110), an H1 receptor antagonist (an antihistamine) and is commonly prescribed to treat allergic and vasomotor rhinitis. There is also some research being conducted on diphenylpyraline derivatives to determine their antimycobacterial and antifungal activity.
Definition
ChEBI: The hydrochloride salt of diphenylpyraline. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders.
Manufacturing Process
A mixture of 46 grams of 1-methyl-4-piperidinol (0.4 mol), 49.4 grams of
benzhydryl
omide (0.2 mol) and 100 ml of xylene was refluxed for
approximately 24 hours. The reaction mixture separated into two phases with
the upper phase containing the desired ether compound dissolved in xylene.
The lower phase consisted of the hydro
omide salt of the excess 1-methyl-4-
piperidinol. The upper phase was separated from the lower phase and the
desired benzhydryl ether recovered in the crude state by distilling off the
xylene under reduced pressure.
The crude benzhydryl ether was a clear reddish oil. It was dissolved in 75 ml
of 20% hydrochloric acid and the aqueous acid solution then washed three
times with 50 ml portions each of ethyl ether. The aqueous acid solution was
then decolorized with activated carbon and thereafter slowly admixed with 75
ml of 28% aqueous ammonia. The benzhydryl ether separated as an oily
material and was removed from the aqueous mixture by extraction with three
50 ml portions of ethyl ether.
On evaporation of the ethyl ether from the ethyl ether solution, the
benzhydryl ether was recovered as a pale yellow oil. The benzhydryl ether was
dissolved in 60 ml of isopropanol and the isopropanol solution acidified to a
pH of 3 with dry hydrogen chloride-methanol solution. The acidic propanol
solution was then diluted with ethyl ether until a faint turbidity was observed.
In a short time, the crystalline hydrochloride salt of the benzhydryl ether
separated from the propanol solution. The crystallized salt was recrystallized
once from 75 ml of isopropanol with the aid of ethyl ether in order to further
purify the material. A yield of the pure hydrochloride salt of 1-methylpiperidyl-
4-benzhydryl ether of 24.5 grams was obtained. This was 39% of the
theoretical yield. The pure material had a melting point of 206°C.
Therapeutic Function
Antihistaminic
General Description
Diphenylpyr alinehydrochloride, 4-(diphenylmethoxy)-1-methylpiperidinehydrochloride (Hispril, Diafen) is a white or slightly offwhitecrystalline powder that is soluble in water or alcohol.Diphenylpyraline is structurally related to diphenhydraminewith the aminoalkyl side chain incorporated in a piperidinering. It is a potent antihistaminic, and the usual dose is 2 mg3 or 4 times daily.
Synthesis
Diphenylpyraline, 4-diphenylmethoxy-1-methylpiperidine (16.1.32), is synthesized by alkylating 4-hydroxy-1-methylpiperidine with benzhydrylbromide.
Diphenylpyraline Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Diphenylpyraline Hydrochloride Suppliers
- Tel
- 0571-8512-5372
- sales@bingochem.com
- Country
- China
- ProdList
- 21669
- Advantage
- 58
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9648
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4891
- Advantage
- 55
- Tel
- 021-50158063
- Fax
- 021-6153 1846
- sales@elivpharma.com
- Country
- China
- ProdList
- 646
- Advantage
- 58
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6463
- Advantage
- 55
- Tel
- 021-58892003
- info@qiaochem.com
- Country
- China
- ProdList
- 5904
- Advantage
- 65
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 18991218082; 13572462239
- Fax
- 029-81494338
- hongyan.zhao@xianpt.com
- Country
- China
- ProdList
- 117
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- +86-27-87465837 +8618971612321
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9639
- Advantage
- 58
- Tel
- +86-0551-65418671 +8618949823763
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34563
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- 86-571-88216897,88216896 13588875226
- Fax
- 86-571-88216895
- sales@hzclap.com
- Country
- CHINA
- ProdList
- 6312
- Advantage
- 58
- Tel
- +86 17788583750
- Fax
- +86 571 85220831
- sales@cyanochem.com
- Country
- CHINA
- ProdList
- 281
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49374
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 18501792038; 18501792038
- shanpel@anpel.com.cn
- Country
- China
- ProdList
- 9611
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4195
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44806
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 021-021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31121
- Advantage
- 58
- Tel
- 13169972583
- 513211116@qq.com
- Country
- China
- ProdList
- 3006
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62075
- Advantage
- 58
- Tel
- 15229059051
- 1027@dideu.com
- Country
- China
- ProdList
- 10006
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 15583
- Advantage
- 58
- Tel
- 021-58000709 15900491054
- info@scrbio.com
- Country
- China
- ProdList
- 10329
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 4997
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 19704
- Advantage
- 58
- Tel
- 4008-099-669
- 23419001name@qq.com
- Country
- CHINA
- ProdList
- 73043
- Advantage
- 58
- Tel
- 18153089275
- 3032079623@qq.com
- Country
- China
- ProdList
- 22695
- Advantage
- 58
- Tel
- +8615858145714
- Fax
- +86-571-56059825
- FandaChem@Gmail.com
- Country
- China
- ProdList
- 9004
- Advantage
- 55
- Tel
- +8613817748580
- Fax
- 021-50175322
- cooperation@kean-chem.com
- Country
- China
- ProdList
- 40066
- Advantage
- 58
- Tel
- +undefined18621343501
- product@acmec-e.com
- Country
- China
- ProdList
- 33338
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43340
- Advantage
- 58
- Tel
- +86-057181025280; +8617767106207
- Fax
- 0571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 49734
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 24727
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@shrbio.com
- Country
- CHINA
- ProdList
- 6871
- Advantage
- 58
- Tel
- --
- Fax
- --
- jingkehuaxue@163.com
- Country
- CHINA
- ProdList
- 6972
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- China
- ProdList
- 6532
- Advantage
- 50