ChemicalBook > CAS DataBase List > AC2-12

AC2-12

Product Name: AC2-12
CAS No.: 256447-08-2
Chemical Name: AC2-12
Synonyms: LPC1;ANX1;ANXA-1;AC2-12;ANNEXIN 1;Annexin A1;AC-AMVSEFLKQAW;Annexin A1 (1-11);Annexin 1 (ANXA - 1;Annexin A1 (1-11) (dephosphorylated)
CBNumber: CB9356865
Molecular Formula: C63H94N14O17S
Formula Weight: 1351.57
MOL File: 256447-08-2.mol

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AC2-12 Property

storage temp.: -20°C
form: Solid
color: White to off-white
biological source: rabbit
Water Solubility: Soluble to 1 mg/ml in 20% acetonitrile / Water
Sequence: Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB1306513
Product name: ANTI-ANNEXIN A1 (CENTER) antibody produced in rabbit
Purity: purified immunoglobulin, buffered aqueous solution
Packaging: 400μl
Price: $496
Updated: 2025/07/31

Tocris

Product number: 1846
Product name: Ac2-12
Packaging: 1
Price: $202
Updated: 2021/12/16

Usbiological

Product number: 381917
Product name: ANXA1
Packaging: 96Tests
Price: $599
Updated: 2021/12/16

Usbiological

Product number: 153519
Product name: Annexin A1
Packaging: 10ug
Price: $316
Updated: 2021/12/16

Usbiological

Product number: 153518
Product name: Annexin A1
Packaging: 10ug
Price: $316
Updated: 2021/12/16

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AC2-12 Chemical Properties,Usage,Production

Uses

Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].

Enzyme inhibitor

This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice.

in vivo

Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)^[1].
Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice^[2].

References

[1] L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14535-9. DOI:10.1073/pnas.95.24.14535
[2] M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73. DOI:10.1016/S0002-9440(10)64667-6

AC2-12 Preparation Products And Raw materials

Raw materials

Preparation Products

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256447-08-2, AC2-12Related Search:

H-LYS-SER-ASP-GLY-GLY-VAL-LYS-LYS-ARG-LYS-SER-SER-SER-SER-OH ASP-LEU-ASP-VAL-PRO-ILE-PRO-GLY-ARG-PHE-ASP-ARG-ARG-VAL-SER-VAL-ALA-ALA-GLU H-MET-HIS-ARG-GLN-GLU-ALA-VAL-ASP-CYS-LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-OH CALP2 CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309) ITSFEEAKGLDRINERMPPRRDAMP ANGIOGENIN (108-122) AC2-26 AC2-12

Annexin A1 (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine) Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine)

Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine)

Annexin A1

ANTI-ANNEXIN A1 (CENTER) antibody produced in rabbit

ANX1

LPC1

Annexin 1 (ANXA - 1

Annexin A1 (1-11) (dephosphorylated)

ANNEXIN 1

ANXA-1

AC-AMVSEFLKQAW

AC-ALA-MET-VAL-SER-GLU-PHE-LEU-LYS-GLN-ALA-TRP-OH

AC2-12

Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH trifluoroacetate salt

Annexin A1 (1-11)

L-Tryptophan, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-

Recombinant Human Annexin A1/ANXA1 Protein, No Tag

256447-08-2

C63H94N14O17S

peptide