GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN
Description Source Background- Product Name
- GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN
- Chemical Name
- GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN
- Synonyms
- GDNF;RHGDNF;GDNF HUMAN;HUMAN GDNF;HUMAN ATF-1;REC GDNF (HUMAN);REC ATF-1 (HUMAN);RECOMBINANT HUMAN GDNF;Human GDNF Protein, Gly & Pro Tag;HUMAN GLIAL-DERIVED NEUROTROPHIC FACTOR
- CBNumber
- CB9361171
- Formula Weight
- 0
- MOL File
- Mol file
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Property
- storage temp.
- -20°C
- form
- lyophilized powder
- color
- white
- biological source
- human
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SRP3309
- Product name
- GDNF human
- Purity
- Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
- Packaging
- 10μG
- Price
- $459
- Updated
- 2025/07/31
- Product number
- G1777
- Product name
- Glial Cell Line-derived Neurotrophic Factor human
- Purity
- recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE)
- Packaging
- 10μG
- Price
- $225
- Updated
- 2025/07/31
- Product number
- 383059
- Product name
- GDNF
- Packaging
- 96Tests
- Price
- $729
- Updated
- 2021/12/16
- Product number
- 383058
- Product name
- GDNF
- Packaging
- 96Tests
- Price
- $729
- Updated
- 2021/12/16
- Product number
- 383057
- Product name
- GDNF
- Packaging
- 96Tests
- Price
- $729
- Updated
- 2021/12/16
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Chemical Properties,Usage,Production
Uses
Glial cell line-derived neurotrophic factor human (GDNF) has been used as a component in the neurobasal medium for neural differentiation. It has also been used for self-renewal, expansion and differentiation of?spermatogonial stem cells (SSCs).
General Description
Glial cell line-derived neurotrophic factor (GDNF) human gene is located on human chromosome 5p13.2.
Biochem/physiol Actions
Glial Cell Line-Derived Neurotrophic Factor is a member of the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF is founding member of the GDNF family of ligands, which to date include GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). GDNF is a glycosylated disulfide-linked homodimeric protein of ~15 kDa. Mature rat and human GDNF share ~93% sequence homology, with strong species cross-reactivity. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using the Parkinson′s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. GDNF promotes survival of various neuronal cells in central and peripheral nervous systems and different stages of development, including motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. In addition, exogenously applied GDNF has been shown to rescue damaged facial motor neurons in vivo.
Description
Glial derived Neurotrophic Factor Human Recombinant produced in E.Coli is a non-glycosylated disulfide-linked homodimer containing 2 x 135 amino acids and having a total molecular mass of approximately 30kDa.
GDNF is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
GDNF promotes the survival and differentiation of minergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.
GDNF enhances survival and morphological differentiation of minergic neurons and increases their high-affinity uptake.
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Suppliers
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