SC 19220
- Product Name
- SC 19220
- CAS No.
- 19395-87-0
- Chemical Name
- SC 19220
- Synonyms
- SC 19220;2-acetylhydrazide 10(11h)-carboxylic acid;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid;N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide;8-CHLORO-DIBENZ[B,F][1,4]OXAZEPINE-10[11H]-CARBOXY-(2-ACETYL)HYDRAZIDE;8-CHLORO-DIBENZ[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-ACETYLHYDRAZIDE;8-CHLORO-DIBENZO[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-ACETYLHYDRAZIDE;Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide;8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacid,2-acetylhydrazide;2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid
- CBNumber
- CB9372348
- Molecular Formula
- C16H14ClN3O3
- Formula Weight
- 331.75
- MOL File
- 19395-87-0.mol
SC 19220 Property
- Melting point:
- 190-191 °C (lit.)
- storage temp.
- Store at RT
- solubility
- DMSO: 10 mg/mL, soluble
- form
- solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- S3065
- Product name
- SC 19220
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $82.4
- Updated
- 2024/03/01
- Product number
- S3065
- Product name
- SC 19220
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $832
- Updated
- 2023/01/07
- Product number
- 14060
- Product name
- SC 19220
- Purity
- ≥96%
- Packaging
- 1mg
- Price
- $20
- Updated
- 2024/03/01
- Product number
- 14060
- Product name
- SC 19220
- Purity
- ≥96%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 14060
- Product name
- SC 19220
- Purity
- ≥96%
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
SC 19220 Chemical Properties,Usage,Production
Uses
SC 19220 is a selective EP1?receptor antagonist.
Uses
SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.
Definition
ChEBI: N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide is an aromatic ether.
Biological Activity
Selective EP 1 receptor antagonist (IC 50 = 6.7 μ M for inhibition of [ 3 H]-PGE 2 binding to EP 1 transfected COS cells).
Biochem/physiol Actions
SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.
storage
Store at RT
SC 19220 Preparation Products And Raw materials
Raw materials
Preparation Products
SC 19220 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
- Tel
- --
- Fax
- --
- kevinbanks@molekula.com
- Country
- United Kingdom
- ProdList
- 6140
- Advantage
- 66