2-(Chloromethyl)pyrimidine
- Product Name
- 2-(Chloromethyl)pyrimidine
- CAS No.
- 54198-88-8
- Chemical Name
- 2-(Chloromethyl)pyrimidine
- Synonyms
- EOS-62429;2-Chlormethyl-pyrimidin;2-chloroMrthyl pyriMidine;2-(CHLOROMETHYL)-PYRIMIDINE;2-(Chloromethyl)pyrimidin...;PYRIMIDINE, 2-(CHLOROMETHYL)-;pyrimidin-2-yl-methyl chloride;Pyrimidine, 2-(chloromethyl)- (9CI);2-(ChloroMethyl)pyriMidine(HCl ForM);2-(Chloromethyl)pyrimidine(HCl salt form)
- CBNumber
- CB9379246
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 54198-88-8.mol
2-(Chloromethyl)pyrimidine Property
- Boiling point:
- 101-103 °C(Press: 26 Torr)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 0.43±0.13(Predicted)
- form
- liquid
- color
- Brown
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 068531
- Product name
- 2-(Chloromethyl)pyrimidine
- Purity
- >95%
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- W6849
- Product name
- 2-(Chloromethyl)pyrimidine
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 3H32-5-CM
- Product name
- 2-(Chloromethyl)pyrimidine
- Packaging
- 1g
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 068531
- Product name
- 2-(Chloromethyl)pyrimidine
- Purity
- >95%
- Packaging
- 5g
- Price
- $425
- Updated
- 2021/12/16
- Product number
- 3H32-5-CM
- Product name
- 2-(Chloromethyl)pyrimidine
- Packaging
- 5G
- Price
- $493
- Updated
- 2021/12/16
2-(Chloromethyl)pyrimidine Chemical Properties,Usage,Production
Synthesis
42839-09-8
54198-88-8
General procedure for the synthesis of 2-(chloromethyl)pyrimidine from 2-pyrimidine methanol: To a stirred solution of pyrimidin-2-ylmethanol (4.5 g, 40.90 mmol) in dichloromethane (DCM, 50 mL) was slowly added thionyl chloride (SOCl2, 10 mL) at 0 °C and protected by an inert atmosphere. The reaction mixture was gradually warmed to 50 °C and stirred continuously for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete conversion of the feedstock, the volatiles were removed by distillation under reduced pressure. The residue was quenched with ice-cold water and subsequently neutralized with saturated sodium bicarbonate (NaHCO3) solution and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography to afford 2-(chloromethyl)pyrimidine in brown liquid form (960 mg, 18% yield). The product was characterized as follows: 1H-NMR (DMSO-d6, 400 MHz): δ8.84 (d, 2H), 7.52 (t, 1H), 4.82 (s, 2H); Mass spectrometry (ESI): m/z 128.5 [M + 1]+; Liquid Chromatography-Mass Spectrometry (LC-MS) purity: 95.09% (column: Chromolith RP-18, 100×4.6 mm; retention time: 3.86 min; mobile phase: 5 mM NH4OAc/acetonitrile (ACN); flow rate: 0.8 mL/min); thin-layer chromatography (TLC) conditions: 70% ethyl acetate/hexane (Rf value: 0.6).
References
[1] Patent: WO2012/40230, 2012, A1. Location in patent: Page/Page column 81
[2] Patent: US4118567, 1978, A
[3] Patent: EP150984, 1991, B1
[4] Patent: US4826833, 1989, A
[5] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0509; 0510
2-(Chloromethyl)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Chloromethyl)pyrimidine manufacturers
- Product
- 2-(Chloromethyl)pyrimidine 54198-88-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14