ChemicalBook > CAS DataBase List > 6-Methylpyridine-3-boronic Acid
6-Methylpyridine-3-boronic Acid
- Product Name
- 6-Methylpyridine-3-boronic Acid
- CAS No.
- 659742-21-9
- Chemical Name
- 6-Methylpyridine-3-boronic Acid
- Synonyms
- (6-METHYLPYRIDIN-3-YL)BORONIC ACID;2-METHYLPYRIDINE-5-BORONIC ACID;2-Methyl-5-boronic acid;2-Picoline-5-boronicaci;2-picolin-5-boronic acid;2-Methyl-5-pyridine acid;2-Picoline-5-boronic acid;6-Methylpyridine-3-Boronic;2-methyl-5-pydineboronic acid;2-METHYL-5-PYRIDINEBORONIC ACID
- CBNumber
- CB9380574
- Molecular Formula
- C6H8BNO2
- Formula Weight
- 136.94
- MOL File
- 659742-21-9.mol
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6-Methylpyridine-3-boronic Acid Property
- Melting point:
- 128-130°C
- Boiling point:
- 294.7±42.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.27±0.10(Predicted)
- form
- Powder
- color
- White to pale brown
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 659742-21-9(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 748404
- Product name
- 6-Methylpyridine-3-boronic acid
- Packaging
- 1g
- Price
- $169.4
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 748404
- Product name
- 6-Methylpyridine-3-boronic acid
- Packaging
- 500mg
- Price
- $130
- Updated
- 2023/01/07
TRC
- Product number
- M326565
- Product name
- 6-Methylpyridine-3-boronic acid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
Usbiological
- Product number
- 281834
- Product name
- 2-Methylpyridine-5-boronic acid
- Packaging
- 500mg
- Price
- $453
- Updated
- 2021/12/16
AK Scientific
- Product number
- X0926
- Product name
- 2-Methylpyridine-5-boronicacid
- Packaging
- 25g
- Price
- $367
- Updated
- 2021/12/16
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6-Methylpyridine-3-boronic Acid Chemical Properties,Usage,Production
Chemical Properties
White to off-white solid
Uses
6-Methylpyridine-3-boronic Acid is used in the preparation of various biologically active compound such as phosphoinositide-3-kinases (PI3K) and c-jun N-terminal kinase (JNK) inhibitors.
Uses
suzuki reaction
Synthesis
111770-91-3
73183-34-3
659742-21-9
General procedure for the synthesis of 6-methyl-3-pyridineboronic acid from 6-methyl-3-pyridinol trifluoromethanesulfonate and bis(pinacolato)diboronate: 6-methyl-3-pyridinol trifluoromethanesulfonate (4.6 mmol) was dissolved in acetonitrile (30 mL) and transferred to a 5 mL microwave reaction tube. To this solution was added 1.5 equivalents of bis(pinacolato)diboron (6.9 mmol; 1.71 g). The mixture was stirred on a magnetic stirrer until complete dissolution. Subsequently, potassium acetate (13.8 mmol; 1.35 g) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (98 mg, 0.03 mol%) were added to the mixture. The reaction mixture was placed in a microwave reactor and heated at 160°C for 2 x 600 seconds. Upon completion of the reaction (monitored by LC-MS), the acetonitrile was removed by evaporation to give a black solid. The solid was dissolved in DMSO and purified by HPLC to give the final target product 6-methyl-3-pyridineboronic acid (580 mg, 92% yield; 4.2 mmol). Mass spectral data: MH+ = 138.
References
[1] Patent: WO2005/32493, 2005, A2. Location in patent: Page/Page column 40-41
[2] Patent: WO2005/32493, 2005, A2. Location in patent: Page/Page column 40-41
6-Methylpyridine-3-boronic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methylpyridine-3-boronic Acid manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- (6-Methylpyridin-3-yl)boronic acid 659742-21-9
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-17
Career Henan Chemical Co
- Product
- 6-Methylpyridine-3-boronic Acid 659742-21-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg;5kg;100kg
- Release date
- 2019-07-04
659742-21-9, 6-Methylpyridine-3-boronic AcidRelated Search:
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